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Details on Person conversion of dUMP to dTMP

Class:Id	Reaction:73605
_displayName	conversion of dUMP to dTMP
_doRelease	TRUE
_timestamp	2025-12-16 18:01:35
catalystActivity	[CatalystActivity:73520] thymidylate synthase activity of TS dimer [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:73446] Jassal, B, 2003-06-17 09:00:25
crossReference	[DatabaseIdentifier:9976230] RHEA:12105
input	[SimpleEntity:109382] dUMP [cytosol] [SimpleEntity:1132205] 5,10-methylenetetrahydrofolate(2-) [cytosol]
internalReviewed	[InstanceEdit:9977060] D'Eustachio, Peter, 2025-12-16
literatureReference	[LiteratureReference:200061] Expression of human thymidylate synthase in Escherichia coli [LiteratureReference:500735] Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors
modified	[InstanceEdit:73832] Jassal, B, 2003-07-03 08:48:35 [InstanceEdit:74362] D'Eustachio, P, 2003-07-18 15:39:00 [InstanceEdit:74382] D'Eustachio, P, 2003-07-18 16:30:00 [InstanceEdit:74394] D'Eustachio, P, 2003-07-21 13:51:00 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:166447] Jassal, B, 2005-09-07 11:02:57 [InstanceEdit:200032] D'Eustachio, P, 2007-07-13 20:48:01 [InstanceEdit:500731] D'Eustachio, P, 2010-02-04 [InstanceEdit:504063] D'Eustachio, P, 2010-02-05 [InstanceEdit:504071] D'Eustachio, P, 2010-02-07 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9976236] D'Eustachio, Peter, 2025-12-09 [InstanceEdit:9977061] D'Eustachio, Peter, 2025-12-16 [InstanceEdit:9977063] D'Eustachio, Peter, 2025-12-16
name	conversion of dUMP to dTMP dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate => 7,8-dihydrofolate + dTMP
output	[SimpleEntity:73604] DHF [cytosol] [SimpleEntity:109366] TMP [cytosol]
precedingEvent	[Reaction:73596] dCMP + H2O => dUMP + NH4+ [Homo sapiens] [Reaction:73598] (2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK) [Homo sapiens] [Reaction:75125] (d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) [Homo sapiens] [Reaction:73666] hydrolysis of 2'-deoxyuridine 5'-triphosphate to form 2'-deoxyuridine 5'-phosphate [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2004-07-06
reviewed	[InstanceEdit:9977064] D'Eustachio, Peter, 2025-12-16
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358370] R-HSA-73605.4
structureModified	[InstanceEdit:9976236] D'Eustachio, Peter, 2025-12-09
summation	[Summation:178325] Cytosolic thymidylate synthase catalyzes the reaction of dUM...
(hasEvent)	[Pathway:499943] Interconversion of nucleotide di- and triphosphates [Homo sapiens]
(precedingEvent)	[Reaction:73635] dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9791196] Update Tracker - [Reaction:73605] dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate - v32:[addLiteratureReference, modifyText] [_UpdateTracker:9792251] Update Tracker - [Reaction:73605] dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate - v22:[addLiteratureReference] [_UpdateTracker:9984726] Update Tracker - [Reaction:73605] conversion of dUMP to dTMP - v96:[add_removeInput]
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