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Details on Person (2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK)

Class:IdReaction:73598
_displayName(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK)
_doReleaseTRUE
_timestamp2025-12-16 18:01:15
catalystActivity[CatalystActivity:73517] nucleoside kinase activity of DCK dimer [cytosol]
catalystActivityReference[CatalystActivityReference:9643457] nucleoside kinase activity of DCK dimer [cytosol] Deoxycytidine kinase from human leukemic spleen: preparation and characterization of the homogeneous enzyme
compartment[Compartment:70101] cytosol
created[InstanceEdit:73446] Jassal, B, 2003-06-17 09:00:25
crossReference[DatabaseIdentifier:9976243] RHEA:24675
[DatabaseIdentifier:9976239] RHEA:46041
input[DefinedSet:500829] Cyt-Rib, dC [cytosol]
[SimpleEntity:113592] ATP [cytosol]
internalReviewed[InstanceEdit:9977060] D'Eustachio, Peter, 2025-12-16
literatureReference[LiteratureReference:109646] Deoxycytidine kinase from human leukemic spleen: preparation and characterization of the homogeneous enzyme
[LiteratureReference:109649] Cloning and expression of human deoxycytidine kinase cDNA
[LiteratureReference:109655] Human T-lymphoblast deoxycytidine kinase: purification and properties
[LiteratureReference:109656] Kinetic properties and inhibition of human T lymphoblast deoxycytidine kinase
[LiteratureReference:109657] The intracellular localization of deoxycytidine kinase
[LiteratureReference:109675] Structure of human dCK suggests strategies to improve anticancer and antiviral therapy
[LiteratureReference:109666] Regulation of purine deoxynucleoside phosphorylation by deoxycytidine kinase from human leukemic blast cells
[LiteratureReference:109681] Nucleotide specificity of human deoxycytidine kinase
[LiteratureReference:109683] Identification of residues involved in the substrate specificity of human and murine dCK
modified[InstanceEdit:74362] D'Eustachio, P, 2003-07-18 15:39:00
[InstanceEdit:74479] D'Eustachio, P, 2003-07-22 16:21:00
[InstanceEdit:109645] D'Eustachio, P, 2004-01-19 14:08:00
[InstanceEdit:109918] D'Eustachio, P, 2004-01-22 15:13:00
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:500827] D'Eustachio, P, 2010-02-05
[InstanceEdit:504063] D'Eustachio, P, 2010-02-05
[InstanceEdit:504071] D'Eustachio, P, 2010-02-07
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:8956390] D'Eustachio, Peter, 2017-01-22
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9976255] D'Eustachio, Peter, 2025-12-09
[InstanceEdit:9977061] D'Eustachio, Peter, 2025-12-16
[InstanceEdit:9977063] D'Eustachio, Peter, 2025-12-16
name(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK)
cytidine + ATP => CMP + ADP + H(+)
2'-deoxycytidine + ATP => dCMP + ADP + H(+)
phosphorylation of 2'-Deoxycytidine to 2'-Deoxycytidine 5'-phosphate
output[DefinedSet:500828] (d)CMP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:70106] H+ [cytosol]
previousReviewStatus[ReviewStatus:9821385] four stars
releaseDate2004-07-06
reviewed[InstanceEdit:9977064] D'Eustachio, Peter, 2025-12-16
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:359927] R-HSA-73598.6
structureModified[InstanceEdit:9976255] D'Eustachio, Peter, 2025-12-09
summation[Summation:178274] Cytosolic deoxycytidine kinase (DCK) catalyzes the reactions...
(hasEvent)[Pathway:73614] Pyrimidine salvage [Homo sapiens]
(precedingEvent)[Reaction:73548] (d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) [Homo sapiens]
[Reaction:73596] dCMP + H2O => dUMP + NH4+ [Homo sapiens]
(replacementInstances)[_Deleted:500831] Deletion of instances: 109687, 109672
(updatedInstance)[_UpdateTracker:9790917] Update Tracker - [Reaction:73598] (2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK) - v32:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]
[_UpdateTracker:9984660] Update Tracker - [Reaction:73598] (2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK) - v96:[removeOutput]
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