Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person conversion of 5,6-dihydrouracil to 3-ureidopropionate

Class:Id	Reaction:73589
_displayName	conversion of 5,6-dihydrouracil to 3-ureidopropionate
_doRelease	TRUE
_timestamp	2025-12-11 22:36:17
catalystActivity	[CatalystActivity:73469] dihydropyrimidinase activity of DPYS tetramer [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:73446] Jassal, B, 2003-06-17 09:00:25
crossReference	[DatabaseIdentifier:9976521] RHEA:16122
input	[SimpleEntity:73584] 5,6-Dihydrouracil [cytosol] [SimpleEntity:29356] H2O [cytosol]
literatureReference	[LiteratureReference:200045] Dihydropyrimidinase deficiency: structural organization, chromosomal localization, and mutation analysis of the human dihydropyrimidinase gene
modified	[InstanceEdit:73832] Jassal, B, 2003-07-03 08:48:35 [InstanceEdit:74362] D'Eustachio, P, 2003-07-18 15:39:00 [InstanceEdit:74479] D'Eustachio, P, 2003-07-22 16:21:00 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:200032] D'Eustachio, P, 2007-07-13 20:48:01 [InstanceEdit:504063] D'Eustachio, P, 2010-02-05 [InstanceEdit:504071] D'Eustachio, P, 2010-02-07 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9737738] D'Eustachio, Peter, 2021-07-21 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9976516] D'Eustachio, Peter, 2025-12-11
name	conversion of 5,6-dihydrouracil to 3-ureidopropionate 5,6-dihydrouracil + H2O => 3-(carbamoylamino)propanoate + H(+)
output	[SimpleEntity:73588] UPROP [cytosol] [SimpleEntity:70106] H+ [cytosol]
precedingEvent	[Reaction:73585] reduction of uracil to form dihydrouracil [Homo sapiens]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361548] R-HSA-73589.5
summation	[Summation:178350] Cytosolic dihydropyrimidinase tetramer catalyzes the reactio...
(hasEvent)	[Pathway:73621] Pyrimidine catabolism [Homo sapiens]
(precedingEvent)	[Reaction:73591] conversion of 3-ureidopropionate to beta-alanine [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775534] Update Tracker - [Reaction:73589] 5,6-dihydrouracil + H2O => beta-ureidopropionate - v78:[addOutput] [_UpdateTracker:9790078] Update Tracker - [Reaction:73589] 5,6-dihydrouracil + H2O => beta-ureidopropionate - v35:[modifyText] [_UpdateTracker:9792300] Update Tracker - [Reaction:73589] 5,6-dihydrouracil + H2O => beta-ureidopropionate - v22:[addLiteratureReference]
[Change default viewing format]

No pathways have been reviewed or authored by conversion of 5,6-dihydrouracil to 3-ureidopropionate (73589)