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Details on Person PRPS dimers pyrophosphorylate R5P using ATP

Class:IdReaction:73580
_displayNamePRPS dimers pyrophosphorylate R5P using ATP
_doReleaseTRUE
_timestamp2025-02-27 16:54:33
catalystActivity[CatalystActivity:111174] ribose phosphate diphosphokinase activity of PRPS dimers [cytosol]
catalystActivityReference[CatalystActivityReference:9643885] ribose phosphate diphosphokinase activity of PRPS2 dimer, PRPS1L dimer [cytosol] Human phosphoribosylpyrophosphate synthetase
compartment[Compartment:70101] cytosol
created[InstanceEdit:73446] Jassal, B, 2003-06-17 09:00:25
crossReference[DatabaseIdentifier:9934050] RHEA:15610
input[SimpleEntity:73578] R5P [cytosol]
[SimpleEntity:113592] ATP [cytosol]
literatureReference[LiteratureReference:111183] Human phosphoribosylpyrophosphate synthetase
[LiteratureReference:9934062] Phosphoribosyl Diphosphate (PRPP): Biosynthesis, Enzymology, Utilization, and Metabolic Significance
modified[InstanceEdit:73832] Jassal, B, 2003-07-03 08:48:35
[InstanceEdit:74268] D'Eustachio, P, 2003-07-17 15:08:00
[InstanceEdit:74269] D'Eustachio, P, 2003-07-17 15:30:00
[InstanceEdit:76019] D'Eustachio, P, 2003-09-12 12:00:00
[InstanceEdit:111173] D'Eustachio, P, 2004-02-09 03:00:00
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:189818] D'Eustachio, P, 2006-12-06 23:20:55
[InstanceEdit:478871] D'Eustachio, P, 2010-01-26
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9934059] Stephan, Ralf, 2025-01-06
[InstanceEdit:9939469] Stephan, Ralf, 2025-02-27
namePRPS dimers pyrophosphorylate R5P using ATP
D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate
addition of diphosphate (PP) to ribose 5-phosphate to form 5'-Phospho-alpha-D-ribose 1-diphosphate (PRPP)
output[SimpleEntity:73566] PRPP [cytosol]
[SimpleEntity:76577] AMP [cytosol]
[SimpleEntity:70106] H+ [cytosol]
precedingEvent
previousReviewStatus[ReviewStatus:9821384] two stars
regulatedBy[Requirement:9034457] Requirement by 'Mg2+ [cytosol]'
[Requirement:9034462] Requirement by 'Pi [cytosol]'
releaseDate2004-07-06
reviewed[InstanceEdit:9939470] Matthews, Lisa, 2025-02-27
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:469644] D'Eustachio, P, 2010-01-24
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:360510] R-HSA-73580.5
structureModified[InstanceEdit:9934059] Stephan, Ralf, 2025-01-06
summation[Summation:178637] Cytosolic phophoribosyl pyrophosphate synthetase catalyzes t...
(hasEvent)[Pathway:73843] 5-Phosphoribose 1-diphosphate biosynthesis [Homo sapiens]
(inferredFrom)[Reaction:1113173] D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate [Oryza sativa]
(orthologousEvent)[Reaction:1113173] D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate [Oryza sativa]
(precedingEvent)[Reaction:73567] UMPS dimer transfers phosphoribosyl group to ORO to form OMP [Homo sapiens]
[Reaction:73815] 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate [Homo sapiens]
(replacementInstances)[_Deleted:189811] Deletion of instance: 111211
[_Deleted:189815] Deletion of instance: 111214
(updatedInstance)[_UpdateTracker:9792530] Update Tracker - [Reaction:73580] D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate - v20:[add_removeCatalystActivity, modifyText]
[_UpdateTracker:9939744] Update Tracker - [Reaction:73580] PRPS dimers pyrophosphorylate R5P using ATP - v92:[modifyText, removeLiteratureReference, removeOutput, removeRegulator]
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