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Details on Person CAD hexamer transforms L-Gln to CAP

Class:IdReaction:73577
_displayNameCAD hexamer transforms L-Gln to CAP
_doReleaseTRUE
_timestamp2025-12-02 23:58:51
authored[InstanceEdit:73446] Jassal, B, 2003-06-17 09:00:25
catalystActivity[CatalystActivity:73458] carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity of CAD hexamer [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:73446] Jassal, B, 2003-06-17 09:00:25
crossReference[DatabaseIdentifier:9975779] RHEA:18634
edited[InstanceEdit:165080] D'Eustachio, P, 0000-00-00 00:00:00
input[SimpleEntity:111627] HCO3- [cytosol]
[SimpleEntity:29472] L-Gln [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:29356] H2O [cytosol]
literatureReference[LiteratureReference:111631] Control of pyrimidine biosynthesis in human lymphocytes. Simultaneous increase in activities of glutamine-utilizing carbamyl phosphate synthetase and aspartate transcarbamylase in phytohemagglutinin-stimulated human peripheral lymphocytes and their enzyme co-purification
[LiteratureReference:111634] Molecular cloning of a human cDNA encoding a trifunctional enzyme of carbamoyl-phosphate synthetase-aspartate transcarbamoylase-dihydroorotase in de Novo pyrimidine synthesis
modified[InstanceEdit:74268] D'Eustachio, P, 2003-07-17 15:08:00
[InstanceEdit:74479] D'Eustachio, P, 2003-07-22 16:21:00
[InstanceEdit:73844] 2007-03-03 09:38:00
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:419505] D'Eustachio, P, 2009-05-01 21:46:52
[InstanceEdit:504063] D'Eustachio, P, 2010-02-05
[InstanceEdit:504071] D'Eustachio, P, 2010-02-07
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9708748] Jassal, Bijay, 2020-12-01
[InstanceEdit:9736390] D'Eustachio, Peter, 2021-07-07
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9975767] D'Eustachio, Peter, 2025-12-02
nameCAD hexamer transforms L-Gln to CAP
hydrogencarbonate + L-glutamine + 2 ATP + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)
L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate
bicarbonate and glutamine combine to form carbamoyl phosphate
output[SimpleEntity:111647] CAP [cytosol]
[SimpleEntity:29404] L-Glu [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29372] Pi [cytosol]
[SimpleEntity:70106] H+ [cytosol]
[SimpleEntity:70106] H+ [cytosol]
releaseDate2004-07-06
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:360134] R-HSA-73577.6
summation[Summation:111630] The synthesis of carbamoyl phosphate from glutamine, bicarbo...
(hasEvent)[Pathway:500753] Pyrimidine biosynthesis [Homo sapiens]
(inferredFrom)[Reaction:419440] L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate [Gallus gallus]
(precedingEvent)[Reaction:73573] CAD hexamer transforms CAP to N-carb-L-Asp [Homo sapiens]
(updatedInstance)[_UpdateTracker:9776007] Update Tracker - [Reaction:73577] CAD hexamer transforms L-Gln to CAP - v78:[addOutput]
[_UpdateTracker:9791542] Update Tracker - [Reaction:73577] CAD hexamer transforms L-Gln to CAP - v29:[modifyText]
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