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Details on Person CAD hexamer transforms CAP to N-carb-L-Asp

Class:Id	Reaction:73573
_displayName	CAD hexamer transforms CAP to N-carb-L-Asp
_doRelease	TRUE
_timestamp	2025-12-02 23:58:50
authored	[InstanceEdit:73446] Jassal, B, 2003-06-17 09:00:25
catalystActivity	[CatalystActivity:73459] aspartate carbamoyltransferase activity of CAD hexamer [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:73446] Jassal, B, 2003-06-17 09:00:25
crossReference	[DatabaseIdentifier:9975766] RHEA:20014
edited	[InstanceEdit:165080] D'Eustachio, P, 0000-00-00 00:00:00
input	[SimpleEntity:111647] CAP [cytosol] [SimpleEntity:29448] L-Asp [cytosol]
literatureReference	[LiteratureReference:111631] Control of pyrimidine biosynthesis in human lymphocytes. Simultaneous increase in activities of glutamine-utilizing carbamyl phosphate synthetase and aspartate transcarbamylase in phytohemagglutinin-stimulated human peripheral lymphocytes and their enzyme co-purification [LiteratureReference:111634] Molecular cloning of a human cDNA encoding a trifunctional enzyme of carbamoyl-phosphate synthetase-aspartate transcarbamoylase-dihydroorotase in de Novo pyrimidine synthesis [LiteratureReference:111640] Oligomeric structure of the multifunctional protein CAD that initiates pyrimidine biosynthesis in mammalian cells
modified	[InstanceEdit:74268] D'Eustachio, P, 2003-07-17 15:08:00 [InstanceEdit:73844] 2007-03-03 09:38:00 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:419505] D'Eustachio, P, 2009-05-01 21:46:52 [InstanceEdit:504063] D'Eustachio, P, 2010-02-05 [InstanceEdit:504071] D'Eustachio, P, 2010-02-07 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9708748] Jassal, Bijay, 2020-12-01 [InstanceEdit:9736390] D'Eustachio, Peter, 2021-07-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9975767] D'Eustachio, Peter, 2025-12-02
name	CAD hexamer transforms CAP to N-carb-L-Asp carbamoyl phosphate + L-aspartate => N-carbamoyl-L-aspartate + phosphate + H(+) carbamoyl phosphate + L-aspartate <=> N-carbamoyl L-aspartate + orthophosphate carbamoyl phosphate and L-aspartate combine to form N-Carbamoyl-L-aspartate
output	[SimpleEntity:111628] N-carb-L-Asp [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:70106] H+ [cytosol]
precedingEvent	[Reaction:73577] CAD hexamer transforms L-Gln to CAP [Homo sapiens]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360780] R-HSA-73573.6
summation	[Summation:111645] The synthesis of N-carbamoyl L-aspartate from carbamoyl phos...
(hasEvent)	[Pathway:500753] Pyrimidine biosynthesis [Homo sapiens]
(inferredFrom)	[Reaction:419451] carbamoyl phosphate + L-aspartate <=> N-carbamoyl L-aspartate + orthophosphate [Gallus gallus]
(precedingEvent)	[Reaction:73571] CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775672] Update Tracker - [Reaction:73573] CAD hexamer transforms CAP to N-carb-L-Asp - v78:[addOutput] [_UpdateTracker:9791515] Update Tracker - [Reaction:73573] CAD hexamer transforms CAP to N-carb-L-Asp - v29:[addLiteratureReference, modifyText]
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