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Details on Person CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO

Class:Id	Reaction:73571
_displayName	CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO
_doRelease	TRUE
_timestamp	2025-12-02 23:58:48
authored	[InstanceEdit:73446] Jassal, B, 2003-06-17 09:00:25
catalystActivity	[CatalystActivity:73460] dihydroorotase activity of CAD hexamer [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:73446] Jassal, B, 2003-06-17 09:00:25
crossReference	[DatabaseIdentifier:9975777] RHEA:24298
edited	[InstanceEdit:165080] D'Eustachio, P, 0000-00-00 00:00:00
input	[SimpleEntity:111628] N-carb-L-Asp [cytosol] [SimpleEntity:70106] H+ [cytosol]
literatureReference	[LiteratureReference:111634] Molecular cloning of a human cDNA encoding a trifunctional enzyme of carbamoyl-phosphate synthetase-aspartate transcarbamoylase-dihydroorotase in de Novo pyrimidine synthesis
modified	[InstanceEdit:74268] D'Eustachio, P, 2003-07-17 15:08:00 [InstanceEdit:77415] D'Eustachio, P, 2003-10-25 14:57:00 [InstanceEdit:73844] 2007-03-03 09:38:00 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:419505] D'Eustachio, P, 2009-05-01 21:46:52 [InstanceEdit:504063] D'Eustachio, P, 2010-02-05 [InstanceEdit:504071] D'Eustachio, P, 2010-02-07 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9708748] Jassal, Bijay, 2020-12-01 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9975767] D'Eustachio, Peter, 2025-12-02
name	CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO N-carbamoyl-L-aspartate + H(+) => (S)-dihydroorotate + H2O N-carbamoyl L-aspartate + H+ <=> (S)-dihydroorotate + H2O condensation of N-Carbamoyl-L-aspartate to form (S)-Dihydroorotate (ring closure)
output	[SimpleEntity:76630] (S)-DHO [cytosol] [SimpleEntity:29356] H2O [cytosol]
precedingEvent	[Reaction:73573] CAD hexamer transforms CAP to N-carb-L-Asp [Homo sapiens] [Reaction:73577] CAD hexamer transforms L-Gln to CAP [Homo sapiens]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359383] R-HSA-73571.5
summation	[Summation:111646] The synthesis of dihydroorotate from N-carbamoyl L-aspartate...
(hasEvent)	[Pathway:500753] Pyrimidine biosynthesis [Homo sapiens]
(inferredFrom)	[Reaction:419465] N-carbamoyl L-aspartate + H+ <=> (S)-dihydroorotate + H2O [Gallus gallus]
(precedingEvent)	[Reaction:73569] DHODH:FMN oxidises (S)-DHO to orotate [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9791520] Update Tracker - [Reaction:73571] CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO - v29:[modifyText]
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