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Details on Person DHODH:FMN oxidises (S)-DHO to orotate

Class:Id	Reaction:73569
_displayName	DHODH:FMN oxidises (S)-DHO to orotate
_doRelease	TRUE
_timestamp	2025-12-02 23:58:52
authored	[InstanceEdit:73446] Jassal, B, 2003-06-17 09:00:25
catalystActivity	[CatalystActivity:73535] dihydroorotate dehydrogenase activity of DHODH:FMN [mitochondrial inner membrane]
compartment	[Compartment:70101] cytosol [Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:73446] Jassal, B, 2003-06-17 09:00:25
crossReference	[DatabaseIdentifier:9975770] RHEA:28692
edited	[InstanceEdit:165080] D'Eustachio, P, 0000-00-00 00:00:00
input	[SimpleEntity:76630] (S)-DHO [cytosol] [SimpleEntity:73663] CoQ [mitochondrial inner membrane]
literatureReference	[LiteratureReference:76627] Pyrimidine nucleotide biosynthesis in animals: genes, enzymes, and regulation of UMP biosynthesis [LiteratureReference:76613] Superoxide production and electron transport in mitochondrial oxidation of dihydroorotic acid [LiteratureReference:76616] Expression, purification, and characterization of histidine-tagged rat and human flavoenzyme dihydroorotate dehydrogenase [LiteratureReference:76621] Indirect inhibition of mitochondrial dihydroorotate dehydrogenase activity by nitric oxide [LiteratureReference:111664] Enzymic synthesis and breakdown of a pyrimidine, orotic acid. I. Dihydro-orotic dehydrogenase
modified	[InstanceEdit:74268] D'Eustachio, P, 2003-07-17 15:08:00 [InstanceEdit:76579] D'Eustachio, P, 2003-10-11 14:30:00 [InstanceEdit:76612] D'Eustachio, P, 2003-10-14 11:15:00 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:419505] D'Eustachio, P, 2009-05-01 21:46:52 [InstanceEdit:504063] D'Eustachio, P, 2010-02-05 [InstanceEdit:504071] D'Eustachio, P, 2010-02-07 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9708748] Jassal, Bijay, 2020-12-01 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9975767] D'Eustachio, Peter, 2025-12-02
name	DHODH:FMN oxidises (S)-DHO to orotate S)-dihydroorotate + a ubiquinone => orotate + a ubiquinol (S)-dihydroorotate + ubiquinone => orotate + ubiquinol oxidation of (S)-Dihydroorotate to form Orotate
output	[SimpleEntity:76632] ORO [cytosol] [SimpleEntity:76633] QH2 [mitochondrial inner membrane]
precedingEvent	[Reaction:73571] CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO [Homo sapiens] [Reaction:73573] CAD hexamer transforms CAP to N-carb-L-Asp [Homo sapiens]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359043] R-HSA-73569.5
summation	[Summation:76631] Dihydroorotate dehydrogenase catalyzes the oxidation of dihy...
(hasEvent)	[Pathway:500753] Pyrimidine biosynthesis [Homo sapiens]
(inferredFrom)	[Reaction:419452] (S)-dihydroorotate + ubiquinone => orotate + ubiquinol [Gallus gallus] [Reaction:1113119] (S)-dihydroorotate + ubiquinone => orotate + ubiquinol [Oryza sativa]
(orthologousEvent)	[Reaction:1113119] (S)-dihydroorotate + ubiquinone => orotate + ubiquinol [Oryza sativa]
(precedingEvent)	[Reaction:73567] UMPS dimer transfers phosphoribosyl group to ORO to form OMP [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9791495] Update Tracker - [Reaction:73569] DHODH:FMN oxidises (S)-DHO to orotate - v29:[addLiteratureReference, modifyText]
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