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Details on Person UMPS dimer transfers phosphoribosyl group to ORO to form OMP

Class:Id	Reaction:73567
_displayName	UMPS dimer transfers phosphoribosyl group to ORO to form OMP
_doRelease	TRUE
_timestamp	2025-12-02 23:58:57
authored	[InstanceEdit:73446] Jassal, B, 2003-06-17 09:00:25
catalystActivity	[CatalystActivity:73491] orotate phosphoribosyltransferase activity of UMPS dimer [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:73446] Jassal, B, 2003-06-17 09:00:25
crossReference	[DatabaseIdentifier:9975778] RHEA:10382
edited	[InstanceEdit:165080] D'Eustachio, P, 0000-00-00 00:00:00
input	[SimpleEntity:76632] ORO [cytosol] [SimpleEntity:73566] PRPP [cytosol]
literatureReference	[LiteratureReference:111648] Molecular cloning of the human UMP synthase gene and characterization of point mutations in two hereditary orotic aciduria families [LiteratureReference:419511] Intrinsic activity and stability of bifunctional human UMP synthase and its two separate catalytic domains, orotate phosphoribosyltransferase and orotidine-5'-phosphate decarboxylase [LiteratureReference:111659] Isolation and initial characterization of the single polypeptide that synthesizes uridine 5'-monophosphate from orotate in Ehrlich ascites carcinoma. Purification by tandem affinity chromatography of uridine-5'-monophosphate synthase [LiteratureReference:419510] Structures of the human orotidine-5'-monophosphate decarboxylase support a covalent mechanism and provide a framework for drug design
modified	[InstanceEdit:73955] Joshi-Tope, G, 2003-07-14 07:52:00 [InstanceEdit:73955] Joshi-Tope, G, 2003-07-14 07:52:00 [InstanceEdit:74268] D'Eustachio, P, 2003-07-17 15:08:00 [InstanceEdit:74269] D'Eustachio, P, 2003-07-17 15:30:00 [InstanceEdit:111216] D'Eustachio, P, 2004-02-10 11:22:00 [InstanceEdit:73844] 2007-03-03 09:38:00 [InstanceEdit:143506] D'Eustachio, P, 2004-11-11 21:16:29 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:189818] D'Eustachio, P, 2006-12-06 23:20:55 [InstanceEdit:189818] D'Eustachio, P, 2006-12-06 23:20:55 [InstanceEdit:419505] D'Eustachio, P, 2009-05-01 21:46:52 [InstanceEdit:504063] D'Eustachio, P, 2010-02-05 [InstanceEdit:504071] D'Eustachio, P, 2010-02-07 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9708748] Jassal, Bijay, 2020-12-01 [InstanceEdit:9736302] D'Eustachio, Peter, 2021-07-06 [InstanceEdit:9736390] D'Eustachio, Peter, 2021-07-07 [InstanceEdit:9748647] D'Eustachio, Peter, 2021-07-23 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9975767] D'Eustachio, Peter, 2025-12-02
name	UMPS dimer transfers phosphoribosyl group to ORO to form OMP orotate + 5-phospho-alpha-D-ribose 1-diphosphate => orotidine 5'-phosphate + diphosphate orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate phosphoribosylation of orotate to form oritidine 5'-phosphate (OMP)
output	[SimpleEntity:111629] OMP [cytosol] [SimpleEntity:111294] PPi [cytosol]
precedingEvent	[Reaction:73569] DHODH:FMN oxidises (S)-DHO to orotate [Homo sapiens] [Reaction:73571] CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO [Homo sapiens] [Reaction:111215] PRPS1 dimer pyrophosphorylates R5P using dATP [Homo sapiens] [Reaction:73580] PRPS dimers pyrophosphorylate R5P using ATP [Homo sapiens] [Reaction:71306] RPIA isomerizes D-ribulose 5-phosphate to ribose 5-phosphate [Homo sapiens]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361913] R-HSA-73567.6
summation	[Summation:111658] The synthesis of orotidine 5'-monophosphate (OMP) from orota...
(hasEvent)	[Pathway:500753] Pyrimidine biosynthesis [Homo sapiens]
(inferredFrom)	[Reaction:419462] orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate [Gallus gallus] [Reaction:1113188] orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate [Oryza sativa]
(orthologousEvent)	[Reaction:1113188] orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate [Oryza sativa]
(precedingEvent)	[Reaction:71732] PPA1 hydrolyzes pyrophosphate to orthophosphate [Homo sapiens] [Reaction:73564] UMPS dimer decarboxylates OMP to UMP [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9791501] Update Tracker - [Reaction:73567] UMPS dimer transfers phosphoribosyl group to ORO to form OMP - v29:[addLiteratureReference, modifyText]
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