Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person UMPS dimer decarboxylates OMP to UMP

Class:Id	Reaction:73564
_displayName	UMPS dimer decarboxylates OMP to UMP
_doRelease	TRUE
_timestamp	2025-12-02 23:58:56
authored	[InstanceEdit:73446] Jassal, B, 2003-06-17 09:00:25
catalystActivity	[CatalystActivity:73492] orotidine-5'-phosphate decarboxylase activity of UMPS dimer [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:73446] Jassal, B, 2003-06-17 09:00:25
crossReference	[DatabaseIdentifier:9975776] RHEA:11597
edited	[InstanceEdit:165080] D'Eustachio, P, 0000-00-00 00:00:00
input	[SimpleEntity:111629] OMP [cytosol] [SimpleEntity:70106] H+ [cytosol]
literatureReference	[LiteratureReference:111648] Molecular cloning of the human UMP synthase gene and characterization of point mutations in two hereditary orotic aciduria families [LiteratureReference:419511] Intrinsic activity and stability of bifunctional human UMP synthase and its two separate catalytic domains, orotate phosphoribosyltransferase and orotidine-5'-phosphate decarboxylase [LiteratureReference:419510] Structures of the human orotidine-5'-monophosphate decarboxylase support a covalent mechanism and provide a framework for drug design [LiteratureReference:111659] Isolation and initial characterization of the single polypeptide that synthesizes uridine 5'-monophosphate from orotate in Ehrlich ascites carcinoma. Purification by tandem affinity chromatography of uridine-5'-monophosphate synthase
modified	[InstanceEdit:73955] Joshi-Tope, G, 2003-07-14 07:52:00 [InstanceEdit:74268] D'Eustachio, P, 2003-07-17 15:08:00 [InstanceEdit:73844] 2007-03-03 09:38:00 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:419505] D'Eustachio, P, 2009-05-01 21:46:52 [InstanceEdit:504063] D'Eustachio, P, 2010-02-05 [InstanceEdit:504071] D'Eustachio, P, 2010-02-07 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9708748] Jassal, Bijay, 2020-12-01 [InstanceEdit:9736390] D'Eustachio, Peter, 2021-07-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9975767] D'Eustachio, Peter, 2025-12-02
name	UMPS dimer decarboxylates OMP to UMP orotidine 5'-phosphate + H(+) => UMP + CO2 orotidine 5'-monophosphate => uridine 5'-monophosphate + CO2 decarboxylation of Orotidine 5'-phosphate to form Uridine 5'-phosphate
output	[SimpleEntity:109402] UMP [cytosol] [SimpleEntity:113528] CO2 [cytosol]
precedingEvent	[Reaction:73567] UMPS dimer transfers phosphoribosyl group to ORO to form OMP [Homo sapiens] [Reaction:73569] DHODH:FMN oxidises (S)-DHO to orotate [Homo sapiens] [Reaction:111215] PRPS1 dimer pyrophosphorylates R5P using dATP [Homo sapiens] [Reaction:73580] PRPS dimers pyrophosphorylate R5P using ATP [Homo sapiens]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359283] R-HSA-73564.6
summation	[Summation:111663] The decarboxylation of orotidine 5'-monophosphate (OMP) to f...
(hasEvent)	[Pathway:500753] Pyrimidine biosynthesis [Homo sapiens]
(inferredFrom)	[Reaction:419461] orotidine 5'-monophosphate => uridine 5'-monophosphate + CO2 [Gallus gallus]
(precedingEvent)	[Reaction:73548] (d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9776004] Update Tracker - [Reaction:73564] UMPS dimer decarboxylates OMP to UMP - v78:[addInput] [_UpdateTracker:9791493] Update Tracker - [Reaction:73564] UMPS dimer decarboxylates OMP to UMP - v29:[addLiteratureReference, modifyText]
[Change default viewing format]

No pathways have been reviewed or authored by UMPS dimer decarboxylates OMP to UMP (73564)