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Details on Person The human gene SLC29A3 encodes the equilibrative nucleoside ...
| Class:Id | Summation:727771 |
|---|---|
| _displayName | The human gene SLC29A3 encodes the equilibrative nucleoside ... |
| _timestamp | 2014-10-23 15:01:18 |
| created | [InstanceEdit:727781] Jassal, Bijay, 2010-05-12 |
| modified | [InstanceEdit:5628739] Jassal, Bijay, 2014-10-23 |
| text | The human gene SLC29A3 encodes the equilibrative nucleoside transporter 3 (ENT3). It is abundant in many tissues, especially the placenta and is localized intracellularly on the lysosomal membrane. SLC29A3 mediates the reversible transport of nucleosides and the nucleobase adenine (Baldwin et al. 2005). Defects in SLC29A3 can cause histiocytosis-lymphadenopathy plus syndrome (HLAS; MIM:602782), an autosomal recessive disorder characterised by combined features from 2 or more of four histiocytic disorders (Molho-Pessach et al. 2008). |
| (summation) | [Reaction:727749] SLC29A3 transports nucleosides from lysosomal lumen to cytosol [Homo sapiens] [Reaction:727767] SLC29A3 transports nucleosides from cytosol to lysosomal lumen [Homo sapiens] |
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