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Details on Person SLC29A3 transports nucleosides from lysosomal lumen to cytosol

Class:Id	Reaction:727749
_displayName	SLC29A3 transports nucleosides from lysosomal lumen to cytosol
_doRelease	TRUE
_timestamp	2025-08-14 08:22:01
authored	[InstanceEdit:727781] Jassal, Bijay, 2010-05-12
catalystActivity	[CatalystActivity:727764] nucleoside transmembrane transporter activity of SLC29A3 [lysosomal membrane]
compartment	[Compartment:70101] cytosol [Compartment:17938] lysosomal membrane [Compartment:161320] lysosomal lumen
created	[InstanceEdit:727781] Jassal, Bijay, 2010-05-12
edited	[InstanceEdit:727781] Jassal, Bijay, 2010-05-12
input	[DefinedSet:727782] nucleosides [lysosomal lumen]
isChimeric	FALSE
literatureReference	[LiteratureReference:727738] Functional characterization of novel human and mouse equilibrative nucleoside transporters (hENT3 and mENT3) located in intracellular membranes [LiteratureReference:727772] The H syndrome is caused by mutations in the nucleoside transporter hENT3
modified	[InstanceEdit:745609] Jassal, Bijay, 2010-05-18 [InstanceEdit:749527] Jassal, Bijay, 2010-05-19 [InstanceEdit:762751] Jassal, Bijay, 2010-05-20 [InstanceEdit:1442515] D'Eustachio, P, 2011-07-12 [InstanceEdit:5628739] Jassal, Bijay, 2014-10-23 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9963497] Stephan, Ralf, 2025-08-14
name	SLC29A3 transports nucleosides from lysosomal lumen to cytosol Equilibrative transport (export) of nucleosides and adenine by solute carrier family 29 (nucleoside transporters), member 3
negativePrecedingEvent	[NegativePrecedingEvent:9963509] Futile Cycle: SLC29A3 transports nucleosides from cytosol to lysosomal lumen
output	[DefinedSet:727746] nucleosides [cytosol]
releaseDate	2010-06-15
reviewed	[InstanceEdit:706449] He, L, 2010-05-10
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105148] R-HSA-727749.3
summation	[Summation:727771] The human gene SLC29A3 encodes the equilibrative nucleoside ...
(hasEvent)	[Pathway:83936] Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane [Homo sapiens]
(normalReaction)	[FailedReaction:5628807] Defective SLC29A3 does not transport nucleosides from lysosomal lumen to cytosol [Homo sapiens]
(precedingEvent)	[Reaction:109529] Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 [Homo sapiens] [Reaction:109534] Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 [Homo sapiens] [Reaction:727768] Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 [Homo sapiens] [NegativePrecedingEvent:9963493] Futile Cycle: SLC29A3 transports nucleosides from lysosomal lumen to cytosol
(updatedInstance)	[_UpdateTracker:9785772] Update Tracker - [Reaction:727749] SLC29A3 transports nucleosides from lysosomal lumen to cytosol - v51:[modifyText]
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