Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Diagram of Neurotransmitter release cycle and Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A)

Class:IdPathwayDiagram:727728
_displayNameDiagram of Neurotransmitter release cycle and Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A)
_timestamp2021-02-24 16:55:53
created[InstanceEdit:727724] Gillespie, ME, 2010-05-12
height2507
modified[InstanceEdit:732469] Gillespie, ME, 2010-05-12
[InstanceEdit:847080] D'Eustachio, P, 2010-05-29
[InstanceEdit:1470802] Gillespie, ME, 2011-08-02
[InstanceEdit:1578457] Gillespie, ME, 2011-09-07
[InstanceEdit:3067318] Jupe, S, 2013-02-06
[InstanceEdit:3076344] Jupe, S, 2013-02-07
[InstanceEdit:3076346] Jupe, S, 2013-02-07
[InstanceEdit:3076910] Jupe, S, 2013-02-07
[InstanceEdit:3077446] Jupe, S, 2013-02-07
[InstanceEdit:3080018] Wu, G, 2013-02-07
[InstanceEdit:5483104] Jupe, Steve, 2014-05-16
[InstanceEdit:5490227] Jupe, Steve, 2014-05-19
[InstanceEdit:5545445] Jupe, Steve, 2014-05-21
[InstanceEdit:5545451] Jupe, Steve, 2014-05-21
[InstanceEdit:5577009] Gillespie, Marc E, 2014-05-28
[InstanceEdit:5604946] Gillespie, Marc E, 2014-07-02
[InstanceEdit:5671867] Jassal, Bijay, 2015-02-03
[InstanceEdit:5676066] Jassal, Bijay, 2015-02-19
[InstanceEdit:5676067] Jassal, Bijay, 2015-02-19
[InstanceEdit:5678247] Jassal, Bijay, 2015-02-23
[InstanceEdit:6789886] Jassal, Bijay, 2015-08-05
[InstanceEdit:8852838] Jassal, Bijay, 2016-01-21
[InstanceEdit:8855180] Wu, G, 2016-02-02
[InstanceEdit:8855182] Gillespie, Marc E, 2016-02-02
[InstanceEdit:8858400] Jassal, Bijay, 2016-02-19
[InstanceEdit:8981133] Jupe, Steve, 2017-03-01
[InstanceEdit:9631054] D'Eustachio, Peter, 2018-12-04
[InstanceEdit:9632232] Jassal, Bijay, 2018-12-17
[InstanceEdit:9671873] Jassal, Bijay, 2019-12-23
[InstanceEdit:9716750] D'Eustachio, Peter, 2021-02-24
representedPathway[Pathway:112310] Neurotransmitter release cycle [Homo sapiens]
[Pathway:5619114] Defective SLC5A7 in the neurotransmitter release cycle causes distal hereditary motor neuronopathy 7A (HMN7A) [Homo sapiens]
storedATXML<?xml version="1.0" encoding="UTF-8"?> <Process nextId="2953" reactomeDiagramId="727728"> <Properties> <displayName>Diagram of Neurotransmitter release cycle and Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A)</displayName> </Properties> <Nodes> <org.gk.render.RenderableChemical id="2" reactomeId="70106" position="214 381" bounds="198 366 32 30" textPosition="201 370"> <Properties> <displayName>H+</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="3" reactomeId="113592" position="208 290" bounds="192 275 32 30" textPosition="193 279"> <Properties> <displayName>ATP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="4" reactomeId="29370" position="393 381" bounds="375 366 37 30" textPosition="377 370" /> <org.gk.render.RenderableChemical id="5" reactomeId="29372" position="393 280" bounds="380 265 27 30" textPosition="384 269"> <Properties> <displayName>Pi</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="6" reactomeId="374900" position="531 327" bounds="515 312 32 30" textPosition="518 316" /> <org.gk.render.RenderableChemical id="8" reactomeId="159362" position="382 460" bounds="366 445 32 30" textPosition="369 449" /> <org.gk.render.RenderableChemical id="9" reactomeId="351601" position="562 454" bounds="546 439 32 30" textPosition="549 443"> <Properties> <displayName>DA</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableProtein id="10" reactomeId="372544" position="445 958" bounds="414 947 63 22" textPosition="415 947"> <Properties> <displayName>SLC18A2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="13" reactomeId="210385" position="1013 877" bounds="990 866 46 22" textPosition="991 866" /> <org.gk.render.RenderableComplex id="16" reactomeId="374911" position="622 1247" bounds="566 1222 112 50" textPosition="570 1223" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Noradrenalin loaded synaptic vesicle</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="18" reactomeId="374939" position="1099 1239" bounds="1037 1207 124 64" textPosition="1047 1208" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Docked Noradrenalin loaded synaptic vesicle</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="20" reactomeId="210374" position="1091 1594" bounds="1026 1576 131 36" textPosition="1028 1577" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableComplex id="21" reactomeId="210441" position="1091 919" bounds="1039 908 105 22" textPosition="1042 909" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableChemical id="22" reactomeId="374935" position="1493 1297" bounds="1477 1282 32 30" textPosition="1480 1280" /> <org.gk.render.RenderableProtein id="23" reactomeId="168786" position="1086 1047" bounds="1067 1036 39 22" textPosition="1068 1036"> <Properties> <displayName>SYT1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="24" reactomeId="374907" position="1088 1089" bounds="1057 1078 63 22" textPosition="1058 1078" /> <org.gk.render.RenderableChemical id="34" reactomeId="209789" position="1735 1296" bounds="1719 1281 32 30" textPosition="1722 1279"> <Properties> <displayName>NAd</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="35" reactomeId="29368" position="1745 1242" bounds="1729 1227 32 30" textPosition="1732 1231"> <Properties> <displayName>O2</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="36" reactomeId="29356" position="1729 1346" bounds="1711 1331 37 30" textPosition="1712 1335"> <Properties> <displayName>H2O</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="37" reactomeId="29382" position="1992 1266" bounds="1976 1251 32 30" textPosition="1979 1249"> <Properties> <displayName>NH3</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="38" reactomeId="29408" position="2048 1312" bounds="2027 1297 42 30" textPosition="2027 1301"> <Properties> <displayName>H2O2</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="40" reactomeId="141332" position="1864 1228" bounds="1828 1217 72 22" textPosition="1839 1204" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MAOA:FAD</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="42" reactomeId="374914" position="1618 1162" bounds="1587 1151 63 22" textPosition="1588 1151"> <Properties> <displayName>SLC22A2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableCompartment id="43" reactomeId="70101" position="560 1251" bounds="27 4 1067 2495" textPosition="75 2436" bgColor="250 240 240" lineColor="255 153 102" insets="46 19 1030 2462"> <Properties> <displayName>cytosol</displayName> </Properties> <Components> <Component id="3" /> <Component id="4" /> <Component id="8" /> <Component id="13" /> <Component id="18" /> <Component id="21" /> <Component id="20" /> <Component id="23" /> <Component id="24" /> <Component id="46" /> <Component id="48" /> <Component id="53" /> <Component id="63" /> <Component id="64" /> <Component id="90" /> <Component id="95" /> <Component id="107" /> <Component id="108" /> <Component id="109" /> <Component id="112" /> <Component id="120" /> <Component id="124" /> <Component id="1" /> <Component id="2" /> <Component id="126" /> <Component id="127" /> <Component id="140" /> <Component id="137" /> <Component id="144" /> <Component id="146" /> <Component id="153" /> <Component id="166" /> <Component id="172" /> <Component id="175" /> <Component id="174" /> <Component id="171" /> <Component id="193" /> <Component id="121" /> <Component id="122" /> <Component id="123" /> <Component id="125" /> <Component id="177" /> <Component id="179" /> <Component id="188" /> <Component id="173" /> <Component id="203" /> <Component id="206" /> <Component id="207" /> <Component id="195" /> <Component id="214" /> <Component id="176" /> <Component id="194" /> <Component id="88" /> <Component id="50" /> <Component id="104" /> <Component id="220" /> <Component id="216" /> <Component id="217" /> <Component id="224" /> <Component id="226" /> <Component id="222" /> <Component id="221" /> <Component id="11" /> <Component id="2284" /> <Component id="2286" /> <Component id="2362" /> <Component id="2438" /> <Component id="2440" /> <Component id="190" /> <Component id="2521" /> <Component id="2584" /> <Component id="213" /> <Component id="148" /> <Component id="2585" /> <Component id="2592" /> <Component id="2596" /> <Component id="2598" /> <Component id="2442" /> <Component id="2605" /> <Component id="2607" /> <Component id="7" /> <Component id="94" /> <Component id="2594" /> <Component id="2610" /> <Component id="136" /> <Component id="54" /> <Component id="2735" /> <Component id="2736" /> <Component id="2737" /> <Component id="2738" /> <Component id="2739" /> <Component id="2898" /> <Component id="2814" /> <Component id="2851" /> <Component id="2945" /> <Component id="2947" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableCompartment id="44" reactomeId="70101" position="1862 1180" bounds="1606 10 512 2341" textPosition="2033 2277" bgColor="250 240 240" lineColor="255 153 102" insets="1621 20 491 2313"> <Components> <Component id="33" /> <Component id="34" /> <Component id="36" /> <Component id="37" /> <Component id="38" /> <Component id="42" /> <Component id="45" /> <Component id="151" /> <Component id="215" /> <Component id="218" /> <Component id="219" /> <Component id="210" /> <Component id="41" /> <Component id="2612" /> <Component id="2616" /> <Component id="149" /> <Component id="2620" /> <Component id="2942" /> <Component id="2943" /> <Component id="2614" /> <Component id="2944" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableCompartment id="45" reactomeId="5460" position="1884 1111" bounds="1771 986 226 250" textPosition="1834 1172" bgColor="250 240 240" lineColor="255 153 102" insets="1785 996 202 230"> <Components> <Component id="40" /> <Component id="35" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableCompartment id="46" reactomeId="374932" position="555 672" bounds="437 266 236 812" textPosition="461 704" bgColor="250 240 240" lineColor="255 153 102" insets="454 280 207 785"> <Properties> <displayName>clathrin-sculpted monoamine transport vesicle lumen</displayName> </Properties> <Components> <Component id="6" /> <Component id="9" /> <Component id="10" /> <Component id="49" /> <Component id="52" /> <Component id="51" /> <Component id="89" /> <Component id="47" /> <Component id="2609" /> <Component id="5" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableChemical id="48" reactomeId="209914" position="377 1030" bounds="361 1015 32 30" textPosition="361 1019" /> <org.gk.render.RenderableChemical id="49" reactomeId="380585" position="541 1028" bounds="525 1013 32 30" textPosition="525 1017"> <Properties> <displayName>5HT</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableEntitySet id="51" reactomeId="380576" position="658 664" bounds="626 653 65 22" textPosition="629 653"> <Properties> <displayName>Synapsin</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="52" reactomeId="380903" position="666 784" bounds="606 766 121 36" textPosition="611 767" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Serotonin loaded synaptic vesicle</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="53" reactomeId="380900" position="1100 809" bounds="1033 784 134 50" textPosition="1042 785" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Docked serotonin loaded synaptic vesicle</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="54" reactomeId="210461" position="1088 1817" bounds="1064 1806 49 22" textPosition="1065 1806" /> <org.gk.render.RenderableProtein id="63" reactomeId="210385" position="998 353" bounds="975 342 46 22" textPosition="976 342" /> <org.gk.render.RenderableProtein id="64" reactomeId="210514" position="978 834" bounds="945 823 67 22" textPosition="946 823" /> <org.gk.render.RenderableChemical id="69" reactomeId="114523" position="1443 999" bounds="1427 984 32 30" textPosition="1427 988" /> <org.gk.render.RenderableComplex id="89" reactomeId="380575" position="655 277" bounds="594 259 123 36" textPosition="598 260" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Dopamine loaded synaptic vesicle</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="90" reactomeId="380573" position="1074 276" bounds="1007 251 134 50" textPosition="1015 252" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Docked dopamine loaded synaptic vesicle</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="92" reactomeId="380873" position="1465 445" bounds="1449 430 32 30" textPosition="1452 434" /> <org.gk.render.RenderableComplex id="94" reactomeId="210441" position="1088 395" bounds="1036 384 105 22" textPosition="1039 385" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableProtein id="95" reactomeId="168786" position="1082 535" bounds="1063 524 39 22" textPosition="1064 524" /> <org.gk.render.RenderableChemical id="105" reactomeId="74113" position="1233 92" bounds="1215 77 37 30" textPosition="1217 81" /> <org.gk.render.RenderableChemical id="106" reactomeId="212615" position="1235 44" bounds="1214 29 42 30" textPosition="1214 33" /> <org.gk.render.RenderableChemical id="107" reactomeId="83910" position="913 101" bounds="895 86 37 30" textPosition="897 90" /> <org.gk.render.RenderableChemical id="108" reactomeId="29472" position="908 50" bounds="887 35 42 30" textPosition="887 39" /> <org.gk.render.RenderableProtein id="109" reactomeId="352093" position="1083 15" bounds="1052 4 63 22" textPosition="1053 4"> <Properties> <displayName>SLC38A2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="111" reactomeId="113522" position="675 102" bounds="654 87 42 30" textPosition="654 91"> <Properties> <displayName>L-Gln</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableCompartment id="112" reactomeId="5460" position="603 131" bounds="403 48 401 167" textPosition="632 173" bgColor="250 240 240" lineColor="255 153 102" insets="413 58 381 147"> <Properties> <displayName>mitochondrial matrix</displayName> </Properties> <Components> <Component id="110" /> <Component id="111" /> <Component id="113" /> <Component id="114" /> <Component id="115" /> <Component id="116" /> <Component id="117" /> <Component id="118" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableChemical id="114" reactomeId="113521" position="686 151" bounds="668 136 37 30" textPosition="669 140" /> <org.gk.render.RenderableChemical id="115" reactomeId="113561" position="514 96" bounds="493 81 42 30" textPosition="497 79"> <Properties> <displayName>NH4+</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="116" reactomeId="113552" position="501 152" bounds="485 137 32 30" textPosition="487 135" /> <org.gk.render.RenderableEntitySet id="117" reactomeId="507859" position="592 81" bounds="553 70 78 22" textPosition="555 70"> <Properties> <displayName>GLS dimers</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableChemical id="119" reactomeId="29404" position="222 1697" bounds="201 1682 42 30" textPosition="201 1686"> <Properties> <displayName>L-Glu</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableCompartment id="120" reactomeId="20592" position="605 1278" bounds="487 1201 237 155" textPosition="500 1310" bgColor="250 240 240" lineColor="255 153 102" insets="497 1211 217 135"> <Properties> <displayName>clathrin-coated endocytic vesicle</displayName> </Properties> <Components> <Component id="16" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableComplex id="122" reactomeId="264795" position="439 1738" bounds="379 1720 120 36" textPosition="383 1721" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Empty Glutamate Synaptic Vesicle</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="123" reactomeId="210380" position="645 1692" bounds="583 1674 125 36" textPosition="588 1675" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Glutamate loaded synaptic vesicle</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableCompartment id="124" reactomeId="349568" position="348 2126" bounds="212 1958 272 336" textPosition="231 2224" bgColor="250 240 240" lineColor="255 153 102" insets="228 1968 246 316"> <Properties> <displayName>clathrin-sculpted glutamate transport vesicle lumen</displayName> </Properties> <Components> <Component id="191" /> <Component id="192" /> <Component id="189" /> <Component id="178" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableComplex id="126" reactomeId="210458" position="1087 1646" bounds="1023 1621 129 50" textPosition="1028 1622" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Docked Glutamate Loaded Synaptic Vesicle</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="127" reactomeId="210475" position="938 1606" bounds="909 1595 59 22" textPosition="910 1595"> <Properties> <displayName>UNC13B</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="137" reactomeId="210357" position="1084 1973" bounds="1053 1962 63 22" textPosition="1054 1962"> <Properties> <displayName>SLC17A7</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="138" reactomeId="210382" position="1509 1811" bounds="1488 1796 42 30" textPosition="1488 1800" /> <org.gk.render.RenderableComplex id="140" reactomeId="210374" position="1083 2012" bounds="1018 1994 131 36" textPosition="1020 1995" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableProtein id="144" reactomeId="210385" position="977 1769" bounds="954 1758 46 22" textPosition="955 1758" /> <org.gk.render.RenderableProtein id="146" reactomeId="210514" position="999 1736" bounds="966 1725 67 22" textPosition="967 1725" /> <org.gk.render.RenderableProtein id="148" reactomeId="168786" position="1089 1461" bounds="1070 1450 39 22" textPosition="1071 1450" /> <org.gk.render.RenderableChemical id="151" reactomeId="29404" position="1751 1810" bounds="1730 1795 42 30" textPosition="1730 1799" /> <org.gk.render.RenderableProtein id="153" reactomeId="210514" position="969 314" bounds="936 303 67 22" textPosition="937 303"> <Properties> <displayName>STXBP1-1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="165" reactomeId="264638" position="1183 2116" bounds="1167 2101 32 30" textPosition="1167 2105"> <Properties> <displayName>Cho</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="166" reactomeId="264618" position="865 2110" bounds="849 2095 32 30" textPosition="849 2099" /> <org.gk.render.RenderableChemical id="172" reactomeId="76183" position="773 2032" bounds="746 2017 54 30" textPosition="746 2021"> <Properties> <displayName>Ac-CoA</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="173" reactomeId="264643" position="576 2007" bounds="554 1992 45 30" textPosition="557 1990"> <Properties> <displayName>AcCho</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="174" reactomeId="76194" position="590 2113" bounds="567 2098 47 30" textPosition="571 2096"> <Properties> <displayName>CoA-SH</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableProtein id="175" reactomeId="264616" position="673 2009" bounds="647 1999 53 20" textPosition="653 1999"> <Properties> <displayName>CHAT</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="177" reactomeId="113592" position="132 1885" bounds="116 1870 32 30" textPosition="117 1874" /> <org.gk.render.RenderableChemical id="178" reactomeId="372511" position="293 1970" bounds="277 1955 32 30" textPosition="280 1959" /> <org.gk.render.RenderableChemical id="179" reactomeId="29370" position="283 1878" bounds="265 1863 37 30" textPosition="267 1867"> <Properties> <displayName>ADP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="188" reactomeId="70106" position="124 1950" bounds="108 1935 32 30" textPosition="111 1939" /> <org.gk.render.RenderableComplex id="190" reactomeId="210372" position="381 1929" bounds="324 1904 114 50" textPosition="331 1905" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Empty Acetylcholine Synaptic Vesicle</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="191" reactomeId="264786" position="382 2167" bounds="324 2142 116 50" textPosition="329 2143" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Acetylcholine Loaded Synaptic Vesicle</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="192" reactomeId="264619" position="471 2093" bounds="440 2082 63 22" textPosition="441 2082" /> <org.gk.render.RenderableCompartment id="193" reactomeId="372525" position="209 1670" bounds="84 1545 250 250" textPosition="87 1726" bgColor="250 240 240" lineColor="255 153 102" insets="94 1555 230 230"> <Properties> <displayName>clathrin-sculpted acetylcholine transport vesicle lumen</displayName> </Properties> <Components> <Component id="119" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableComplex id="195" reactomeId="372534" position="1092 2168" bounds="1030 2136 124 64" textPosition="1040 2137" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Docked acetylcholine loaded Synaptic Vesicle</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="203" reactomeId="210374" position="1092 2478" bounds="1027 2460 131 36" textPosition="1029 2461" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RIMS1:UNC13B:BZRAP1:Alpha-liprin</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="206" reactomeId="210385" position="983 2244" bounds="960 2233 46 22" textPosition="961 2233"> <Properties> <displayName>CPLX1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="207" reactomeId="210514" position="960 2211" bounds="927 2200 67 22" textPosition="928 2200" /> <org.gk.render.RenderableChemical id="209" reactomeId="372533" position="1487 2291" bounds="1462 2274 50 34" textPosition="1464 2280" /> <org.gk.render.RenderableProtein id="210" reactomeId="372513" position="1611 2249" bounds="1580 2238 63 22" textPosition="1581 2238"> <Properties> <displayName>SLC18A3</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="213" reactomeId="168786" position="1090 2386" bounds="1071 2375 39 22" textPosition="1072 2375" /> <org.gk.render.RenderableComplex id="214" reactomeId="210441" position="1091 2265" bounds="1039 2254 105 22" textPosition="1042 2255" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>SNARE complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.ProcessNode id="215" reactomeId="888590" position="1395 40" bounds="1332 11 127 58" textPosition="1336 11"> <Properties> <displayName>GABA synthesis, release, reuptake and degradation</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableProtein id="216" reactomeId="449128" position="1090 962" bounds="1067 951 47 22" textPosition="1068 951"> <Properties> <displayName>STX1A</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="217" reactomeId="2029017" position="1081 465" bounds="1052 454 58 22" textPosition="1054 454"> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.29310344827586204" relativeY="0.0" label="Pa" description="Cyc" trackId="0" reactomeId="5244496" /> <org.gk.render.RenderableFeature relativeX="0.603448275862069" relativeY="0.0" label="Pa" description="Cyc" trackId="1" reactomeId="5244508" /> <org.gk.render.RenderableFeature relativeX="1.0" relativeY="0.7272727272727273" label="Pa" description="Cyc" trackId="2" reactomeId="5244495" /> <org.gk.render.RenderableFeature relativeX="0.7068965517241379" relativeY="1.0" label="Pa" description="Cyc" trackId="3" reactomeId="5244510" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableEntitySet id="218" reactomeId="2901780" position="1615 1219" bounds="1595 1208 41 22" textPosition="1597 1188"> <Properties> <displayName>SLC22A1,SLC22A2</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableProtein id="220" reactomeId="429572" position="1085 2061" bounds="1057 2049 57 24" textPosition="1059 2050"> <Properties> <displayName>SLC5A7</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="221" reactomeId="449128" position="1087 1377" bounds="1064 1366 47 22" textPosition="1065 1366" /> <org.gk.render.RenderableProtein id="222" reactomeId="2029017" position="1087 1413" bounds="1058 1402 58 22" textPosition="1060 1402"> <Properties> <displayName>SNAP25</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.29310344827586204" relativeY="0.0" label="Pa" description="Cyc" trackId="0" reactomeId="5244496" /> <org.gk.render.RenderableFeature relativeX="0.603448275862069" relativeY="0.0" label="Pa" description="Cyc" trackId="1" reactomeId="5244508" /> <org.gk.render.RenderableFeature relativeX="1.0" relativeY="0.7272727272727273" label="Pa" description="Cyc" trackId="2" reactomeId="5244495" /> <org.gk.render.RenderableFeature relativeX="0.7068965517241379" relativeY="1.0" label="Pa" description="Cyc" trackId="3" reactomeId="5244510" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="224" reactomeId="449128" position="1086 2300" bounds="1063 2289 47 22" textPosition="1064 2289" /> <org.gk.render.RenderableProtein id="226" reactomeId="2029017" position="1088 2340" bounds="1059 2324 58 33" textPosition="1061 2330"> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.29310344827586204" relativeY="0.0" label="Pa" description="Cyc" trackId="0" reactomeId="5244496" /> <org.gk.render.RenderableFeature relativeX="0.603448275862069" relativeY="0.0" label="Pa" description="Cyc" trackId="1" reactomeId="5244508" /> <org.gk.render.RenderableFeature relativeX="1.0" relativeY="0.7272727272727273" label="Pa" description="Cyc" trackId="2" reactomeId="5244495" /> <org.gk.render.RenderableFeature relativeX="0.7068965517241379" relativeY="1.0" label="Pa" description="Cyc" trackId="3" reactomeId="5244510" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="2284" reactomeId="2029017" position="1081 1898" bounds="1052 1887 58 22" textPosition="1054 1887"> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.29310344827586204" relativeY="0.0" label="Pa" description="Cyc" trackId="0" reactomeId="5244496" /> <org.gk.render.RenderableFeature relativeX="0.603448275862069" relativeY="0.0" label="Pa" description="Cyc" trackId="1" reactomeId="5244508" /> <org.gk.render.RenderableFeature relativeX="1.0" relativeY="0.7272727272727273" label="Pa" description="Cyc" trackId="2" reactomeId="5244495" /> <org.gk.render.RenderableFeature relativeX="0.7068965517241379" relativeY="1.0" label="Pa" description="Cyc" trackId="3" reactomeId="5244510" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="2286" reactomeId="449128" position="1083 1772" bounds="1060 1761 47 22" textPosition="1061 1761" /> <org.gk.render.RenderableComplex id="2362" reactomeId="210441" position="1091 1346" bounds="1039 1335 105 22" textPosition="1042 1336" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableProtein id="2438" reactomeId="2029017" position="1086 1004" bounds="1057 993 58 22" textPosition="1059 993"> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.29310344827586204" relativeY="0.0" label="Pa" description="Cyc" trackId="0" reactomeId="5244496" /> <org.gk.render.RenderableFeature relativeX="0.603448275862069" relativeY="0.0" label="Pa" description="Cyc" trackId="1" reactomeId="5244508" /> <org.gk.render.RenderableFeature relativeX="1.0" relativeY="0.7272727272727273" label="Pa" description="Cyc" trackId="2" reactomeId="5244495" /> <org.gk.render.RenderableFeature relativeX="0.7068965517241379" relativeY="1.0" label="Pa" description="Cyc" trackId="3" reactomeId="5244510" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="2440" reactomeId="449128" position="1078 431" bounds="1055 420 47 22" textPosition="1056 420" /> <org.gk.render.RenderableProtein id="2442" reactomeId="210461" position="1086 628" bounds="1062 617 49 22" textPosition="1063 617"> <Properties> <displayName>RAB3A</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="2521" reactomeId="374907" position="1082 577" bounds="1051 566 63 22" textPosition="1052 566" /> <org.gk.render.RenderableProtein id="2584" reactomeId="210461" position="1086 2433" bounds="1062 2422 49 22" textPosition="1063 2422" /> <org.gk.render.RenderableProtein id="2585" reactomeId="210514" position="1001 1280" bounds="968 1269 67 22" textPosition="969 1269" /> <org.gk.render.RenderableProtein id="2592" reactomeId="210385" position="1025 1315" bounds="1002 1304 46 22" textPosition="1003 1304" /> <org.gk.render.RenderableProtein id="2594" reactomeId="210461" position="1087 1543" bounds="1063 1532 49 22" textPosition="1064 1532" /> <org.gk.render.RenderableComplex id="2596" reactomeId="210374" position="1089 1175" bounds="1024 1157 131 36" textPosition="1026 1158" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableProtein id="2598" reactomeId="374907" position="1096 1499" bounds="1065 1488 63 22" textPosition="1066 1488" /> <org.gk.render.RenderableProtein id="2605" reactomeId="210461" position="1092 1125" bounds="1068 1114 49 22" textPosition="1069 1114" /> <org.gk.render.RenderableComplex id="2607" reactomeId="210374" position="1082 684" bounds="1017 666 131 36" textPosition="1019 667" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableEntitySet id="2609" reactomeId="380576" position="672 928" bounds="640 917 65 22" textPosition="643 917" /> <org.gk.render.RenderableChemical id="2610" reactomeId="74016" position="1009 1690" bounds="988 1675 42 30" textPosition="989 1679"> <Properties> <displayName>Ca2+</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="2611" reactomeId="351626" position="1535 1844" bounds="1519 1829 32 30" textPosition="1522 1833" /> <org.gk.render.RenderableChemical id="2612" reactomeId="29804" position="1751 1752" bounds="1735 1737 32 30" textPosition="1738 1741"> <Properties> <displayName>K+</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="2613" reactomeId="74126" position="1509 1752" bounds="1493 1737 32 30" textPosition="1496 1741" /> <org.gk.render.RenderableProtein id="2614" reactomeId="2980942" position="1665 1930" bounds="1636 1920 58 21" textPosition="1637 1920"> <Properties> <displayName>ARL6IP5</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="2616" reactomeId="70106" position="1708 1844" bounds="1692 1829 32 30" textPosition="1695 1833" /> <org.gk.render.RenderableChemical id="2618" reactomeId="74113" position="1537 1884" bounds="1519 1869 37 30" textPosition="1521 1873" /> <org.gk.render.RenderableChemical id="2620" reactomeId="83910" position="1710 1884" bounds="1692 1869 37 30" textPosition="1694 1873"> <Properties> <displayName>Na+</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableEntitySet id="2736" reactomeId="5336428" position="1085 114" bounds="1052 103 66 22" textPosition="1056 97"> <Properties> <displayName>LIN7A,B,C</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableProtein id="2737" reactomeId="5336459" position="995 131" bounds="971 120 49 22" textPosition="972 120"> <Properties> <displayName>APBA1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="2738" reactomeId="373631" position="973 158" bounds="954 147 39 22" textPosition="958 141"> <Properties> <displayName>CASK</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="2739" reactomeId="5336456" position="1083 203" bounds="1026 192 114 22" textPosition="1027 193" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>LIN7:CASK:APBA1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="2812" reactomeId="188972" position="1222 2077" bounds="1205 2062 35 30" textPosition="1209 2066" /> <org.gk.render.RenderableChemical id="2814" reactomeId="352022" position="943 2071" bounds="926 2056 35 30" textPosition="930 2060"> <Properties> <displayName>Cl-</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="2898" reactomeId="83910" position="977 2036" bounds="959 2021 37 30" textPosition="961 2025" /> <org.gk.render.RenderableChemical id="2900" reactomeId="74113" position="1175 2041" bounds="1157 2026 37 30" textPosition="1159 2030" /> <org.gk.render.RenderableChemical id="2930" reactomeId="1605715" position="1793 2168" bounds="1772 2153 42 30" textPosition="1776 2157" /> <org.gk.render.RenderableEntitySet id="2931" reactomeId="6803725" position="1771 2123" bounds="1751 2112 41 22" textPosition="1752 2112"> <Properties> <displayName>NAEs</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="2932" reactomeId="6803778" position="1944 2165" bounds="1929 2154 31 22" textPosition="1930 2154"> <Properties> <displayName>FAs</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableChemical id="2933" reactomeId="6803745" position="1972 2123" bounds="1953 2108 39 30" textPosition="1957 2112"> <Properties> <displayName>ETA</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="2934" reactomeId="6803758" position="1868 2078" bounds="1828 2067 81 22" textPosition="1828 2068" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NAAA dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableCompartment id="2942" reactomeId="161320" position="1874 2139" bounds="1716 2040 317 198" textPosition="1812 2194" bgColor="250 240 240" lineColor="255 153 102" insets="1725 2050 300 180"> <Properties> <displayName>lysosomal lumen</displayName> </Properties> <Components> <Component id="2931" /> <Component id="2932" /> <Component id="2933" /> <Component id="2934" /> <Component id="2929" /> <Component id="2930" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableChemical id="2943" reactomeId="5279533" position="2015 1392" bounds="1948 1363 134 58" textPosition="1950 1367"> <Properties> <displayName>3,4-dihydroxyphenylglycolaldehyde</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableEntitySet id="2944" reactomeId="427969" position="1614 1747" bounds="1568 1736 92 22" textPosition="1569 1736"> <Properties> <displayName>SLC1A1-3,6,7</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="2945" reactomeId="9670771" position="1072 1857" bounds="1020 1839 104 36" textPosition="1020 1840" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>SNARE complex:Ca2+</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="2947" reactomeId="168786" position="1086 1943" bounds="1067 1932 39 22" textPosition="1068 1932" /> </Nodes> <Edges> <org.gk.render.RenderableReaction id="1" reactomeId="374916" points="280 332, 325 333, 367 333" position="325 333" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="2" points="233 369" /> <Input id="3" points="227 299" /> </Inputs> <Outputs> <Output id="4" points="384 363" /> <Output id="5" points="385 298" /> <Output id="6" points="512 327" /> </Outputs> <Properties> <displayName>Re-acidification of clathrin sculpted monoamine tranport vesicle lumen</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="7" reactomeId="372542" points="401 457, 436 453, 543 453" position="436 453" lineWidth="1.0"> <Inputs> <Input id="8" /> </Inputs> <Outputs> <Output id="9" /> </Outputs> <Catalysts> <Catalyst id="10" points="444 944" /> </Catalysts> <Properties> <displayName>Loading of dopamine into synaptic veiscles</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="11" reactomeId="374922" points="789 1244, 848 1244, 1034 1240" position="848 1244" lineWidth="1.0"> <Inputs> <Input id="20" points="1075 1573" /> <Input id="16" points="681 1245" /> <Input id="2592" points="999 1308" /> <Input id="221" points="1061 1366" /> <Input id="222" points="1067 1399" /> <Input id="2585" points="965 1274" /> </Inputs> <Outputs> <Output id="18" /> </Outputs> <Catalysts> <Catalyst id="16" points="681 1237, 849 1208" /> </Catalysts> <Properties> <displayName>Noradrenalin synaptic vesicle docking and priming</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="19" reactomeId="374899" points="1164 1247, 1242 1258, 1413 1296" position="1242 1258" lineWidth="1.0"> <Inputs> <Input id="18" /> </Inputs> <Outputs> <Output id="22" points="1474 1296" /> <Output id="20" points="1110 1573" /> <Output id="148" points="1112 1451" /> <Output id="2585" points="1038 1281" /> <Output id="2362" points="1147 1337" /> <Output id="2592" points="1051 1313" /> <Output id="2594" points="1101 1529" /> <Output id="2598" points="1113 1485" /> </Outputs> <Catalysts> <Catalyst id="18" points="1164 1230, 1250 1218" /> </Catalysts> <Properties> <displayName>Release of noradrenaline at the synapse</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="33" reactomeId="374909" points="1827 1293, 1864 1292, 1920 1318" position="1864 1292" lineWidth="1.0"> <Inputs> <Input id="34" points="1754 1295" /> <Input id="35" points="1764 1251" /> <Input id="36" points="1751 1335" /> </Inputs> <Outputs> <Output id="2943" points="1977 1360" /> <Output id="38" points="2024 1312" /> <Output id="37" points="1973 1277" /> </Outputs> <Catalysts> <Catalyst id="40" points="1864 1242" /> </Catalysts> <Properties> <displayName>Metabolism of Noradrenaline</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="41" reactomeId="374896" points="1512 1296, 1615 1296, 1716 1296" position="1615 1296" lineWidth="1.0"> <Inputs> <Input id="22" /> </Inputs> <Outputs> <Output id="34" /> </Outputs> <Catalysts> <Catalyst id="218" points="1615 1236" /> </Catalysts> <Properties> <displayName>Uptake of Noradrenaline</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="47" reactomeId="380586" points="396 1029, 443 1029, 522 1028" position="443 1029" lineWidth="1.0"> <Inputs> <Input id="48" /> </Inputs> <Outputs> <Output id="49" /> </Outputs> <Catalysts> <Catalyst id="10" points="444 972" /> </Catalysts> <Properties> <displayName>loading of Serotonin in synaptic vesicles</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="50" reactomeId="380905" points="780 783, 888 783, 1030 800" position="888 783" lineWidth="1.0"> <Inputs> <Input id="52" points="730 783" /> <Input id="64" points="942 825" /> <Input id="2438" points="1070 990" /> <Input id="2609" points="680 911" /> <Input id="2596" points="1074 1154" /> <Input id="216" points="1070 948" /> <Input id="13" points="987 867" /> </Inputs> <Outputs> <Output id="53" /> </Outputs> <Catalysts> <Catalyst id="52" points="730 776, 890 757" /> </Catalysts> <Properties> <displayName>Serotonin loaded synaptic vesicle docking and priming</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="68" reactomeId="380901" points="1146 837, 1233 880, 1364 950" position="1233 880" lineWidth="1.0"> <Inputs> <Input id="53" /> </Inputs> <Outputs> <Output id="64" points="1015 844" /> <Output id="21" points="1147 924" /> <Output id="23" points="1109 1040" /> <Output id="69" points="1424 989" /> <Output id="24" points="1109 1075" /> <Output id="13" points="1039 881" /> <Output id="2596" points="1111 1154" /> <Output id="2605" points="1109 1111" /> <Output id="2609" points="711 929" /> </Outputs> <Catalysts> <Catalyst id="53" points="1170 823, 1250 842" /> </Catalysts> <Properties> <displayName>Release of docked serotonin loaded synaptic vesicle</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="88" reactomeId="380574" points="779 276, 912 277, 1004 276" position="912 277" lineWidth="1.0"> <Inputs> <Input id="51" points="661 647" /> <Input id="89" points="720 276" /> <Input id="217" points="1063 451" /> <Input id="63" points="972 344" /> <Input id="153" points="933 307" /> <Input id="2440" points="1056 417" /> <Input id="2607" points="1068 663" /> </Inputs> <Outputs> <Output id="90" /> </Outputs> <Catalysts> <Catalyst id="89" points="720 260, 758 250, 911 250" /> </Catalysts> <Activators> <Activator id="2739" points="1057 217" /> </Activators> <Properties> <displayName>Dopamine synaptic vesicle docking and priming</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="91" reactomeId="380869" points="1139 304, 1186 319, 1370 396" position="1186 319" lineWidth="1.0"> <Inputs> <Input id="90" /> </Inputs> <Outputs> <Output id="92" points="1446 436" /> <Output id="51" points="687 647" /> <Output id="153" points="1006 320" /> <Output id="63" points="1024 355" /> <Output id="2442" points="1099 614" /> <Output id="95" points="1105 525" /> <Output id="94" points="1144 395" /> <Output id="2521" points="1099 563" /> <Output id="2607" points="1100 663" /> </Outputs> <Catalysts> <Catalyst id="90" points="1144 286, 1196 296" /> </Catalysts> <Properties> <displayName>Release of docked dopamine loaded synaptic vesicle</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="104" reactomeId="212642" points="1166 61, 1083 60, 1010 61" position="1083 60" lineWidth="1.0"> <Inputs> <Input id="105" points="1212 83" /> <Input id="106" points="1211 49" /> </Inputs> <Outputs> <Output id="107" points="935 93" /> <Output id="108" points="932 52" /> </Outputs> <Catalysts> <Catalyst id="109" points="1083 29" /> </Catalysts> <Properties> <displayName>L-Glutamine transport into neurons</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="110" reactomeId="212651" points="884 57, 770 102, 699 102" position="770 102" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="108" /> </Inputs> <Outputs> <Output id="111" /> </Outputs> <Properties> <displayName>Transport of L-Glutamine (cytosol) to mitochondrial matrix</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="113" reactomeId="70609" points="649 133, 594 131, 564 132" position="594 131" lineWidth="1.0"> <Inputs> <Input id="114" points="665 142" /> <Input id="111" points="662 120" /> </Inputs> <Outputs> <Output id="115" points="534 114" /> <Output id="116" points="520 146" /> </Outputs> <Catalysts> <Catalyst id="117" points="592 98" /> </Catalysts> <Properties> <displayName>glutamine + H2O =&gt; glutamate + NH4+ [GLS]</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="118" reactomeId="212658" points="482 151, 409 151, 84 152, 220 1679" position="409 151" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="116" /> </Inputs> <Outputs> <Output id="119" /> </Outputs> <Properties> <displayName>Tranport of L-Glutamate (mitochondrial matrix) to cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="121" reactomeId="210444" points="490 1695, 524 1697, 580 1694" position="524 1697" lineWidth="1.0"> <Inputs> <Input id="122" points="460 1717" /> <Input id="119" points="246 1696" /> </Inputs> <Outputs> <Output id="123" /> </Outputs> <Catalysts> <Catalyst id="122" points="502 1737, 518 1737" /> </Catalysts> <Properties> <displayName>L-Glutamate loading of synaptic vesicle</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="125" reactomeId="210426" points="796 1683, 892 1683, 1020 1658" position="892 1683" lineWidth="1.0"> <Inputs> <Input id="123" points="711 1688" /> <Input id="146" points="963 1727" /> <Input id="2286" points="1057 1779, 968 1808" /> <Input id="144" points="951 1758" /> <Input id="2284" points="1049 1894, 944 1882" /> <Input id="140" points="1015 2004, 964 1999" /> </Inputs> <Outputs> <Output id="126" /> </Outputs> <Catalysts> <Catalyst id="123" points="711 1680, 888 1649" /> </Catalysts> <Activators> <Activator id="127" points="931 1620" /> </Activators> <Properties> <displayName>Glutamate synaptic vesicle docking and priming</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="136" reactomeId="210430" points="1085 1697, 1085 1721, 1164 1731" position="1085 1721" lineWidth="1.0"> <Inputs> <Input id="2610" points="1033 1691" /> <Input id="126" points="1086 1674" /> </Inputs> <Outputs> <Output id="54" points="1097 1803" /> <Output id="137" points="1087 1959" /> <Output id="138" points="1485 1806" /> <Output id="2945" points="1087 1878, 1174 1972" /> <Output id="140" points="1088 1991" /> <Output id="146" points="1007 1750, 1158 1943" /> <Output id="144" points="998 1783, 1150 1856" /> <Output id="2947" points="1104 1957, 1200 2011" /> </Outputs> <Catalysts> <Catalyst id="126" points="1096 1674, 1106 1694" /> </Catalysts> <Activators> <Activator id="2610" points="1033 1698" /> </Activators> <Properties> <displayName>Release of L-Glutamate at the synapse</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="149" reactomeId="210404" points="1613 1811, 1615 1810, 1614 1809" position="1615 1810" lineWidth="1.0"> <Inputs> <Input id="2611" points="1554 1837" /> <Input id="2612" points="1732 1758" /> <Input id="138" points="1533 1811" /> <Input id="2618" stoichiometry="3" points="1552 1866" /> </Inputs> <Outputs> <Output id="2613" points="1528 1760" /> <Output id="151" points="1727 1809" /> <Output id="2616" points="1689 1838" /> <Output id="2620" stoichiometry="3" points="1689 1869" /> </Outputs> <Catalysts> <Catalyst id="2944" points="1614 1764" /> </Catalysts> <Inhibitors> <Inhibitor id="2614" points="1656 1917, 1615 1866" /> </Inhibitors> <Properties> <displayName>SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="171" reactomeId="264622" points="719 2068, 678 2068, 643 2068" position="678 2068" lineWidth="1.0"> <Inputs> <Input id="172" points="750 2050" /> <Input id="166" points="846 2105" /> </Inputs> <Outputs> <Output id="173" points="592 2025" /> <Output id="174" points="607 2095" /> </Outputs> <Catalysts> <Catalyst id="175" points="673 2022" /> </Catalysts> <Properties> <displayName>Cho is acetylated to AcCho by CHAT</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="176" reactomeId="349520" points="164 1921, 204 1919, 234 1920" position="204 1919" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="177" points="145 1903" /> <Input id="188" points="143 1938" /> </Inputs> <Outputs> <Output id="178" points="274 1956" /> <Output id="179" points="265 1896" /> </Outputs> <Properties> <displayName>Re-acidification of acetylcholine transport vesicles</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="189" reactomeId="264615" points="381 2029, 381 2090, 382 2119" position="381 2090" lineWidth="1.0"> <Inputs> <Input id="190" points="381 1957" /> <Input id="178" stoichiometry="2" points="312 1980" /> <Input id="173" points="551 2009" /> </Inputs> <Outputs> <Output id="191" points="382 2139" /> <Output id="188" stoichiometry="2" points="143 1960" /> </Outputs> <Catalysts> <Catalyst id="192" points="437 2091" /> </Catalysts> <Properties> <displayName>Loading of acetylcholine in synaptic vesicles</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="194" reactomeId="372505" points="689 2168, 927 2169, 1027 2168" position="927 2169" lineWidth="1.0"> <Inputs> <Input id="191" points="443 2167" /> <Input id="226" points="1056 2327" /> <Input id="203" points="1068 2457" /> <Input id="207" points="924 2205" /> <Input id="206" points="957 2238" /> <Input id="224" points="1060 2292" /> </Inputs> <Outputs> <Output id="195" /> </Outputs> <Catalysts> <Catalyst id="191" points="443 2164, 928 2143" /> </Catalysts> <Properties> <displayName>Acetylcholine synaptic vesicle docking and priming</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="208" reactomeId="372529" points="1157 2181, 1257 2203, 1353 2237" position="1257 2203" lineWidth="1.0"> <Inputs> <Input id="195" /> </Inputs> <Outputs> <Output id="210" points="1577 2247" /> <Output id="209" points="1459 2280" /> <Output id="203" points="1111 2457" /> <Output id="207" points="997 2213" /> <Output id="206" points="1009 2243" /> <Output id="213" points="1109 2372" /> <Output id="214" points="1147 2259" /> <Output id="2584" points="1100 2419" /> </Outputs> <Catalysts> <Catalyst id="195" points="1157 2170, 1271 2175" /> </Catalysts> <Properties> <displayName>Release of acetylcholine at the synapse</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="219" points="1617 1176, 1615 1202" position="1616 1189" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="42" /> </Inputs> <Outputs> <Output id="218" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="2735" reactomeId="5336443" points="1084 157, 1083 157, 1083 189" position="1083 157" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2736" points="1084 131" /> <Input id="2737" points="1023 138" /> <Input id="2738" points="996 157" /> </Inputs> <Outputs> <Output id="2739" /> </Outputs> <Properties> <displayName>LIN7, CASK and APBA1 bind</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2851" reactomeId="429594" points="1129 2099, 1086 2099, 1037 2099" position="1086 2099" lineWidth="1.0"> <Inputs> <Input id="165" points="1164 2110" /> <Input id="2812" points="1202 2081" /> <Input id="2900" points="1163 2059" /> </Inputs> <Outputs> <Output id="166" points="884 2108" /> <Output id="2814" points="964 2076" /> <Output id="2898" points="991 2054" /> </Outputs> <Catalysts> <Catalyst id="220" points="1085 2076" /> </Catalysts> <Properties> <displayName>SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2929" reactomeId="6803753" points="1825 2123, 1868 2123, 1914 2123" position="1868 2123" lineWidth="1.0"> <Inputs> <Input id="2930" points="1803 2150" /> <Input id="2931" points="1798 2123" /> </Inputs> <Outputs> <Output id="2932" points="1936 2148" /> <Output id="2933" points="1950 2123" /> </Outputs> <Catalysts> <Catalyst id="2934" points="1868 2092" /> </Catalysts> <Properties> <displayName>NAAA hydrolyses NAEs to FAs and ethanolamine</displayName> </Properties> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process>
width2126
[Change default viewing format]
No pathways have been reviewed or authored by Diagram of Neurotransmitter release cycle and Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A) (727728)
Follow Reactome