Query author contributions in Reactome
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Details on Person The cap-binding complex is constituted by the initiation fac...
| Class:Id | Summation:72743 |
|---|---|
| _displayName | The cap-binding complex is constituted by the initiation fac... |
| _timestamp | 2011-07-19 13:56:31 |
| modified | [InstanceEdit:75001] Gillespie, ME, 2003-08-07 00:00:00 [InstanceEdit:1454908] D'Eustachio, P, 2011-07-19 |
| text | The cap-binding complex is constituted by the initiation factors eIF4A, eIF4G and eIF4E. First, eIF4E must be released from the inactive eIF4E:4E-BP complex. Then eIF4A interacts with eIF4G, and eIF4E binds to the amino-terminal domain of eIF4G, resulting in the formation of the cap-binding complex eIF4F. eIF4A together with eIF4B or eIF4H is thought to unwind RNA secondary structures near the 5'-end of the mRNA. The translation initiation complex is formed when the 43S complex binds the cap-bound mRNA. |
| (summation) | [Pathway:72662] Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S [Homo sapiens] |
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No pathways have been reviewed or authored by The cap-binding complex is constituted by the initiation fac... (72743)
