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Details on Person eIF2 activation

Class:Id	Reaction:72722
_displayName	eIF2 activation
_doRelease	TRUE
_timestamp	2016-11-10 00:55:49
catalystActivity	[CatalystActivity:72528] translation initiation factor activity of eIF2B subunits complex [cytosol]
compartment	[Compartment:70101] cytosol
input	[Complex:72529] eIF2:GDP: eIF2B [cytosol] [Homo sapiens] [SimpleEntity:29438] GTP [cytosol]
literatureReference	[LiteratureReference:72723] The catalytic mechanism of guanine nucleotide exchange factor action and competitive inhibition by phosphorylated eukaryotic initiation factor 2 [LiteratureReference:72727] Mechanism of the nucleotide exchange reaction in eukaryotic polypeptide chain initiation. Characterization of the guanine nucleotide exchange factor as a GTP-binding protein
modified	[InstanceEdit:110066] Joshi-Tope, G, 2004-01-26 13:16:45 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	eIF2 activation
output	[Complex:72531] eIF2:GTP [cytosol] [Homo sapiens] [SimpleEntity:29420] GDP [cytosol] [Complex:72526] eIF2B subunits complex [cytosol] [Homo sapiens]
precedingEvent	[Reaction:72670] Formation of eIF2:GDP:eIF2B intermediate [Homo sapiens] [Reaction:72619] eIF2:GTP is hydrolyzed, eIFs are released [Homo sapiens]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360299] R-HSA-72722.3
summation	[Summation:72730] eIF2B is a guanine nucleotide releasing factor that is requi...
(hasEvent)	[Pathway:72731] Recycling of eIF2:GDP [Homo sapiens]
(inferredFrom)	[Reaction:1113161] eIF2 activation [Oryza sativa]
(orthologousEvent)	[Reaction:1113161] eIF2 activation [Oryza sativa]
(precedingEvent)	[Reaction:72669] Met-tRNAi binds to eIF2:GTP to form the ternary complex [Homo sapiens]
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No pathways have been reviewed or authored by eIF2 activation (72722)