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Details on Person Cap-bound mRNA is activated by helicases

Class:Id	BlackBoxEvent:72647
_displayName	Cap-bound mRNA is activated by helicases
_doRelease	TRUE
_timestamp	2018-07-13 21:42:26
catalystActivity	[CatalystActivity:72645] RNA helicase activity of eIF4A subunits complex [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:72607] Merrick, WC, 2002-12-16 00:00:00
input	[Complex:72597] eIF4F:mRNP [cytosol] [Homo sapiens] [Complex:72576] eIF4A subunits complex [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:72589] EIF4B [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:72591] EIF4H [cytosol] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol]
literatureReference	[LiteratureReference:72636] New initiation factor activity required for globin mRNA translation
modified	[InstanceEdit:113517] Schmidt, EE, 2004-06-09 05:19:12 [InstanceEdit:113852] Joshi-Tope, G, 2004-06-23 21:17:01 [InstanceEdit:157310] Matthews, L, 2004-12-20 20:22:01 [InstanceEdit:157803] Matthews, L, 2005-01-07 14:09:10 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:188731] Gopinathrao, G, 2006-10-26 20:29:35 [InstanceEdit:194432] Schmidt, EE, 2007-03-13 12:36:16 [InstanceEdit:2648976] D'Eustachio, P, 2012-11-21 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9613506] Gillespie, Marc E, 2018-07-13 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Cap-bound mRNA is activated by helicases
output	[Complex:72593] mRNA:eIF4F:eIF4B:eIF4H [cytosol] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29372] Pi [cytosol] [OtherEntity:72595] RNA-binding protein in RNP (ribonucleoprotein) complexes [cytosol] [Complex:72576] eIF4A subunits complex [cytosol] [Homo sapiens]
precedingEvent	[Reaction:72635] eIF4F binds to mRNP [Homo sapiens] [Reaction:72631] Formation of the cap-binding eIF4F complex [Homo sapiens] [Reaction:75098] mRNP complex dissociates from cytosolic face of NPC [Homo sapiens] [Reaction:158447] Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC [Homo sapiens] [Reaction:159050] Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex [Homo sapiens] [Reaction:158484] Release of the SLBP independent Histone mRNA from the NPC [Homo sapiens]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358895] R-HSA-72647.4
summation	[Summation:72648] The DEAD-box RNA helicase eIF4A, together with the RNA-bindi...
(hasEvent)	[Pathway:72662] Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S [Homo sapiens]
(precedingEvent)	[Reaction:156808] Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation [Homo sapiens] [Reaction:157849] Formation of translation initiation complexes containing mRNA that does not circularize [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9779080] Update Tracker - [BlackBoxEvent:72647] Cap-bound mRNA is activated by helicases - v66:[removeCatalystActivity]
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