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Details on Person eIF2:GTP is hydrolyzed, eIFs are released

Class:Id	Reaction:72619
_displayName	eIF2:GTP is hydrolyzed, eIFs are released
_doRelease	TRUE
_timestamp	2021-08-03 16:37:06
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:72607] Merrick, WC, 2002-12-16 00:00:00
input	[Complex:72594] 48S complex [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:72616] EIF5 [cytosol] [Homo sapiens] [OtherEntity:72617] eIF1 [cytosol]
literatureReference	[LiteratureReference:72677] Binding and release of radiolabeled eukaryotic initiation factors 2 and 3 during 80 S initiation complex formation [LiteratureReference:72650] The mechanism of action of protein synthesis initiation factors from rabbit reticulocytes [LiteratureReference:72652] Initiation of mammalian protein synthesis. II. The assembly of the initiation complex with purified initiation factors [LiteratureReference:72713] Function of eukaryotic initiation factor 5 in the formation of an 80 S ribosomal polypeptide chain initiation complex [LiteratureReference:72715] The joining of ribosomal subunits in eukaryotes requires eIF5B [LiteratureReference:72708] A multifactor complex of eukaryotic initiation factors, eIF1, eIF2, eIF3, eIF5, and initiator tRNA(Met) is an important translation initiation intermediate in vivo
modified	[InstanceEdit:113852] Joshi-Tope, G, 2004-06-23 21:17:01 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:2656454] D'Eustachio, P, 2012-11-23 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9749431] Matthews, Lisa, 2021-08-03 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	eIF2:GTP is hydrolyzed, eIFs are released
output	[Complex:72508] 40S:Met-tRNAi:mRNA [cytosol] [Homo sapiens] [Complex:72530] eIF2:GDP [cytosol] [Homo sapiens] [SimpleEntity:29372] Pi [cytosol] [EntityWithAccessionedSequence:72616] EIF5 [cytosol] [Homo sapiens] [Complex:72555] eIF3 subunits complex [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:72557] EIF1AX [cytosol] [Homo sapiens] [Complex:72576] eIF4A subunits complex [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:72589] EIF4B [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:72578] EIF4E [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:72584] EIF4G1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:72591] EIF4H [cytosol] [Homo sapiens]
precedingEvent	[Reaction:72697] Start codon recognition [Homo sapiens] [Reaction:72621] Ribosomal scanning [Homo sapiens]
regulatedBy	[Requirement:72782] Requirement by 'EIF5 [cytosol]'
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359529] R-HSA-72619.5
summation	[Summation:72756] Once the Met-tRNAi has recognized the AUG, eIF2-bound GTP is...
(hasEvent)	[Pathway:72706] GTP hydrolysis and joining of the 60S ribosomal subunit [Homo sapiens]
(precedingEvent)	[Reaction:72670] Formation of eIF2:GDP:eIF2B intermediate [Homo sapiens] [Reaction:72672] The 60S subunit joins the translation initiation complex [Homo sapiens]
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No pathways have been reviewed or authored by eIF2:GTP is hydrolyzed, eIFs are released (72619)