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Details on Person EIF4G1 [cytosol]
Class:Id EntityWithAccessionedSequence:72584
_displayName EIF4G1 [cytosol]
_timestamp 2013-05-03 18:44:20
compartment [Compartment:70101] cytosol
endCoordinate 1599
modified [InstanceEdit:113604] Schmidt, EE, 2004-06-09 05:34:08 [InstanceEdit:141986] Schmidt, EE, 2004-10-07 15:29:44 [InstanceEdit:3132750] Wu, G, 2013-02-13 [InstanceEdit:3322333] Wu, G, 2013-05-03 [InstanceEdit:3322334] Wu, G, 2013-05-03
name EIF4G1 eIF4G eIF-4-gamma eIF-4G eukaryotic translation initiation factor 4 gamma P220 Eukaryotic translation initiation factor 4 gamma p220
referenceEntity [ReferenceGeneProduct:72583] UniProt:Q04637 EIF4G1 [Homo sapiens]
species [Species:48887] Homo sapiens
stableIdentifier [StableIdentifier:367970] R-HSA-72584.1
startCoordinate 1
(hasComponent) [Complex:72587] eIF4F [cytosol] [Homo sapiens] [Complex:377125] mLST8:mTOR:Raptor:eIF4E:eIF3:eIF4G:eIF1:eIF1A:eIF5:eIF4A:Phospho eIF4B-P:Phospho 40S ribosomal complex:ternary complex [cytosol] [Homo sapiens] [Complex:377130] mLST8:mTOR:Raptor:eIF4E:eIF3:eIF4G:eIF1:eIF1A:eIF5:eIF4A:40S ribosomal complex:ternary complex [cytosol] [Homo sapiens] [Complex:377365] mLST8:mTOR:Raptor:eIF4E:eIF3:eIF4G:eIF1:eIF1A:eIF5:eIF4A:Phospho 40S ribosomal complex:ternary complex [cytosol] [Homo sapiens] [Complex:429977] Translatable mRNA Complex [cytosol] [Homo sapiens] [Complex:429989] Partially Deadenylated mRNA Complex [cytosol] [Homo sapiens] [Complex:450623] AUF1 Complexed with Translation and Heat Shock Proteins [cytosol] [Homo sapiens] [Complex:927743] mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] [Homo sapiens] [Complex:927823] mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] [Homo sapiens] [Complex:927845] mRNA Cleaved by SMG6 [cytosol] [Homo sapiens]
(hasMember) [DefinedSet:1678828] EIF4G [cytosol] [Homo sapiens]
(inferredFrom) [DefinedSet:1113590] Homologues of eIF4G [cytosol] [Oryza sativa] [EntityWithAccessionedSequence:1114134] Q69S49 [cytosol] [Oryza sativa] [EntityWithAccessionedSequence:1114154] Q7XT80 [cytosol] [Oryza sativa] [EntityWithAccessionedSequence:1114168] Q5Z5Q3 [cytosol] [Oryza sativa] [EntityWithAccessionedSequence:1114284] B9FTI7 [cytosol] [Oryza sativa] [EntityWithAccessionedSequence:1114481] A2X746 [cytosol] [Oryza sativa]
(input) [Reaction:72631] Formation of the cap-binding eIF4F complex [Homo sapiens] [Reaction:165766] Phosphorylation and activation of eIF4G by activated S6K1 [Homo sapiens] [Reaction:377258] Formation of the preinitiation complex (PIC) [Homo sapiens] [Reaction:450551] AUF1 binds translation and heat shock proteins [Homo sapiens] [BlackBoxEvent:9014610] Translation of ROBO3.2 mRNA initiates NMD [Homo sapiens]
(output) [Reaction:72619] eIF2:GTP is hydrolyzed, eIFs are released [Homo sapiens] [Reaction:429955] CCR4-NOT complex deadenylates mRNA [Homo sapiens] [Reaction:429992] PARN deadenylates mRNA [Homo sapiens] [BlackBoxEvent:927830] Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex [Homo sapiens]
(requiredInputComponent) [Reaction:156808] Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation [Homo sapiens]
(updatedInstance) [_UpdateTracker:9877984] Update Tracker - [EntityWithAccessionedSequence:72584] EIF4G1 [cytosol] - v44:[modifyEndCoordinate] [_UpdateTracker:9880921] Update Tracker - [EntityWithAccessionedSequence:72584] EIF4G1 [cytosol] - v45:[addName]
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Pathways
No pathways have been reviewed or authored by EIF4G1 [cytosol] (72584)