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Details on Person UniProt:Q04637 EIF4G1

Class:IdReferenceGeneProduct:72583
_chainChangeLogchain:1-1599 added on Fri February 6 2015;initiator methionine: for 72583 added on Sun February 16 2020;initiator methionine: for 72583 removed on Fri Aug 15 2025;initiator methionine:1 for 72583 added on Fri Aug 15 2025
_displayNameUniProt:Q04637 EIF4G1
_timestamp2025-08-15 21:53:32
chainchain:1-1599
initiator methionine:1
checksum324088B60863DA34
commentFUNCTION Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139).SUBUNIT eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E (cap-binding) and EIF4G1/EIF4G3 (PubMed:7651417, PubMed:7935836, PubMed:9372926). Interacts with eIF3 complex, mutually exclusive with EIF4A1 or EIF4A2, EIF4E and through its N-terminus with PABPC1 (PubMed:10970864, PubMed:10996799, PubMed:12086624, PubMed:16698552, PubMed:7651417, PubMed:7935836, PubMed:9372926, PubMed:9857202). Interacts with EIF4E or with EIF1 (mutually exclusive) through a common binding site (PubMed:29987188). Interacts through its C-terminus with the serine/threonine kinases MKNK1, and with MKNK2 (PubMed:11154262, PubMed:9878069). Appears to act as a scaffold protein, holding these enzymes in place to phosphorylate EIF4E (PubMed:11154262, PubMed:9878069). Non-phosphorylated EIF4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation (PubMed:8521827). EIF4G1/EIF4G3 interacts with PABPC1 to bring about circularization of the mRNA (PubMed:10970864, PubMed:10996799, PubMed:12086624, PubMed:9857202). Interacts with EIF4E3 (By similarity). Interacts with CIRBP and MIF4GD (PubMed:10970864, PubMed:10996799, PubMed:16513844, PubMed:18025107). Interacts with RBM4 (PubMed:17284590). Interacts with HNRNPD/AUF1; the interaction requires RNA (PubMed:24423872). Interacts with DDX3X; the interaction requires RNA (PubMed:22872150). Interacts with DAZAP2 (PubMed:17984221).SUBUNIT (Microbial infection) Interacts with rotavirus A NSP3; in this interaction, NSP3 takes the place of PABPC1 thereby inducing shutoff of host protein synthesis.SUBUNIT (Microbial infection) Interacts with human adenovirus 5 protein 100K; this interaction promotes translational shunt in presence of polysomes containing viral tripartite leader mRNAs.SUBUNIT (Microbial infection) Interacts with viral genome-linked protein (via c-terminus); this interaction plays a role in the translation of viral proteins.INTERACTION Phosphorylated at multiple sites in vivo. Phosphorylation at Ser-1185 by PRKCA induces binding to MKNK1.PTM Following infection by certain enteroviruses, rhinoviruses and aphthoviruses, EIF4G1 is cleaved by the viral protease 2A, or the leader protease in the case of aphthoviruses. This shuts down the capped cellular mRNA transcription.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS Produced by alternative initiation at Met-41 of isoform A.MISCELLANEOUS Produced by alternative initiation at Met-88 of isoform A.MISCELLANEOUS Produced by alternative initiation at Met-165 of isoform A.MISCELLANEOUS Produced by alternative initiation at Met-197 of isoform A.MISCELLANEOUS Produced by alternative splicing.MISCELLANEOUS Produced by alternative splicing.MISCELLANEOUS Produced by alternative splicing.SIMILARITY Belongs to the eukaryotic initiation factor 4G family.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Aberrant splicing.
descriptionrecommendedName: Eukaryotic translation initiation factor 4 gamma 1 shortName: eIF-4-gamma 1 shortName: eIF-4G 1 shortName: eIF-4G1 alternativeName: p220
geneNameEIF4G1
EIF4F
EIF4G
EIF4GI
identifierQ04637
isSequenceChangedFALSE
keyword3D-structure
Acetylation
Alternative initiation
Alternative splicing
Cytoplasm
Disease variant
Host-virus interaction
Initiation factor
Methylation
Neurodegeneration
Nucleus
Parkinson disease
Parkinsonism
Phosphoprotein
Protein biosynthesis
Proteomics identification
Reference proteome
RNA-binding
Translation regulation
Translational shunt
modified[InstanceEdit:9836292] Weiser, Joel, 2023-05-25
[InstanceEdit:9841277] Weiser, Joel
[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
[InstanceEdit:9917590] Weiser, Joel, 2024-08-09
[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
[InstanceEdit:9963647] Weiser, Joel, 2025-08-15
nameEIF4G1
referenceDatabase[ReferenceDatabase:2] UniProt
referenceGene[ReferenceDNASequence:9000631] ENSEMBL:ENSG00000114867 EIF4G1 [Homo sapiens]
secondaryIdentifierIF4G1_HUMAN
D3DNT2
D3DNT4
D3DNT5
E9PFM1
G5E9S1
O43177
O95066
Q5HYG0
Q6ZN21
Q8N102
sequenceLength1599
species[Species:48887] Homo sapiens
(isoformParent)[ReferenceIsoform:232519] UniProt:Q04637-3 EIF4G1 [Homo sapiens]
[ReferenceIsoform:232520] UniProt:Q04637-4 EIF4G1 [Homo sapiens]
[ReferenceIsoform:232521] UniProt:Q04637-5 EIF4G1 [Homo sapiens]
[ReferenceIsoform:232522] UniProt:Q04637-6 EIF4G1 [Homo sapiens]
[ReferenceIsoform:405157] UniProt:Q04637-1 EIF4G1 [Homo sapiens]
[ReferenceIsoform:8969685] UniProt:Q04637-7 EIF4G1 [Homo sapiens]
[ReferenceIsoform:8969686] UniProt:Q04637-8 EIF4G1 [Homo sapiens]
[ReferenceIsoform:8969687] UniProt:Q04637-9 EIF4G1 [Homo sapiens]
(referenceEntity)[EntityWithAccessionedSequence:72584] EIF4G1 [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:165762] p-S1108,S1148,S1192-EIF4G1 [cytosol] [Homo sapiens]
(referenceSequence)[ModifiedResidue:165760] O-phospho-L-serine at 1231
[ModifiedResidue:165763] O-phospho-L-serine at 1147
[ModifiedResidue:165764] O-phospho-L-serine at 1185
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No pathways have been reviewed or authored by UniProt:Q04637 EIF4G1 (72583)