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Details on Person UniProt:O15371 EIF3D
| Class:Id | ReferenceGeneProduct:72547 |
|---|---|
| _chainChangeLog | chain:1-548 added on Fri February 6 2015 |
| _displayName | UniProt:O15371 EIF3D |
| _timestamp | 2024-11-03 20:09:49 |
| chain | chain:1-548 |
| checksum | 7FE0448EC3BE1711 |
| comment | FUNCTION mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs (PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:18599441, PubMed:25849773). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs (PubMed:27462815).FUNCTION (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426).SUBUNIT Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.SUBUNIT (Microbial infection) Interacts with Norwalk virus VPg protein (PubMed:12773399).INTERACTION The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of EIF3D into the full eukaryotic translation initiation factor 3 (eIF-3) complex.MASS SPECTROMETRY Defects in EIF3D are associated with some cancers, such as prostate, breast and colon cancers. Disease susceptibility may be associated with variants affecting the gene represented in this entry. Down-regulation inhibits proliferation of cancers (PubMed:25322666, PubMed:25370813, PubMed:25682860, PubMed:26008152, PubMed:26036682, PubMed:26617750, PubMed:27035563).SIMILARITY Belongs to the eIF-3 subunit D family. |
| description | recommendedName: fullName evidence="3"Eukaryotic translation initiation factor 3 subunit D shortName evidence="3"eIF3d alternativeName: fullName evidence="3"Eukaryotic translation initiation factor 3 subunit 7 alternativeName: fullName evidence="3"eIF-3-zeta alternativeName: eIF3 p66 |
| geneName | EIF3D EIF3S7 |
| identifier | O15371 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Cytoplasm Host-virus interaction Initiation factor Phosphoprotein Protein biosynthesis Proteomics identification Reference proteome RNA-binding |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | EIF3D |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8997139] ENSEMBL:ENSG00000100353 EIF3D [Homo sapiens] |
| secondaryIdentifier | EIF3D_HUMAN A8MWD3 B2R7D4 B4DTF8 B4DVY1 Q3MJD9 Q5M9Q6 |
| sequenceLength | 548 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8977808] UniProt:O15371-1 EIF3D [Homo sapiens] [ReferenceIsoform:8977809] UniProt:O15371-2 EIF3D [Homo sapiens] [ReferenceIsoform:8977810] UniProt:O15371-3 EIF3D [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:72548] EIF3D [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O15371 EIF3D (72547)
