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Details on Person UniProt:Q13347 EIF3I
| Class:Id | ReferenceGeneProduct:72535 |
|---|---|
| _chainChangeLog | chain:1-325 added on Sat February 7 2015 |
| _displayName | UniProt:Q13347 EIF3I |
| _timestamp | 2024-11-03 20:09:49 |
| chain | chain:1-325 |
| checksum | 02797BB72A752A96 |
| comment | FUNCTION Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).SUBUNIT Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.INTERACTION Phosphorylated by TGF-beta type II receptor.MASS SPECTROMETRY Belongs to the eIF-3 subunit I family. |
| description | recommendedName: fullName evidence="1"Eukaryotic translation initiation factor 3 subunit I shortName evidence="1"eIF3i alternativeName: fullName evidence="1"Eukaryotic translation initiation factor 3 subunit 2 alternativeName: TGF-beta receptor-interacting protein 1 shortName: TRIP-1 alternativeName: fullName evidence="1"eIF-3-beta alternativeName: fullName evidence="1"eIF3 p36 |
| geneName | EIF3I EIF3S2 TRIP1 |
| identifier | Q13347 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Cytoplasm Direct protein sequencing Initiation factor Isopeptide bond Phosphoprotein Protein biosynthesis Proteomics identification Reference proteome Repeat Ubl conjugation WD repeat |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | EIF3I |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9002932] ENSEMBL:ENSG00000084623 EIF3I [Homo sapiens] |
| secondaryIdentifier | EIF3I_HUMAN |
| sequenceLength | 325 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:72536] EIF3I [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q13347 EIF3I (72535)
