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Details on Person UniProt:P62917 RPL8
| Class:Id | ReferenceGeneProduct:72489 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-257 added on Fri February 6 2015;initiator methionine:1 for 72489 removed on Fri Nov 03 2023;initiator methionine: for 72489 added on Fri Nov 03 2023;initiator methionine: for 72489 removed on Fri Aug 15 2025;initiator methionine:1 for 72489 added on Fri Aug 15 2025 |
| _displayName | UniProt:P62917 RPL8 |
| _timestamp | 2025-08-15 21:10:40 |
| chain | initiator methionine:1 chain:2-257 |
| checksum | CE1610449749318B |
| comment | FUNCTION Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.SUBUNIT Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). Interacts with CRY1 (By similarity).INTERACTION Hydroxylated on His-216 by RIOX1. The modification is impaired by hypoxia.MISCELLANEOUS This protein can be partially incorporated into E.coli polysomes in vivo, indicating it can replace the endogenous protein.SIMILARITY Belongs to the universal ribosomal protein uL2 family. |
| description | recommendedName: fullName evidence="10"Large ribosomal subunit protein uL2 alternativeName: 60S ribosomal protein L8 |
| geneName | RPL8 |
| identifier | P62917 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cytoplasm Direct protein sequencing Hydroxylation Isopeptide bond Proteomics identification Reference proteome Ribonucleoprotein Ribosomal protein RNA-binding rRNA-binding Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | RPL8 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9003778] ENSEMBL:ENSG00000161016 RPL8 [Homo sapiens] |
| secondaryIdentifier | RL8_HUMAN A8K094 D3DWN2 P25120 Q567Q7 Q969V7 Q9BWQ9 |
| sequenceLength | 257 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:72490] RPL8 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9630976] 3OHH216-RPL8 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9630985] RPL8 [nucleoplasm] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:9630979] modified L-histidine residue at 216 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P62917 RPL8 (72489)
