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Details on Person UniProt:P46777 RPL5
| Class:Id | ReferenceGeneProduct:72481 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-297 added on Fri February 6 2015;initiator methionine:1 for 72481 removed on Fri Nov 03 2023;initiator methionine: for 72481 added on Fri Nov 03 2023;initiator methionine: for 72481 removed on Fri Aug 15 2025;initiator methionine:1 for 72481 added on Fri Aug 15 2025 |
| _displayName | UniProt:P46777 RPL5 |
| _timestamp | 2025-08-15 21:18:25 |
| chain | initiator methionine:1 chain:2-297 |
| checksum | 07CA9FBA842BD2A3 |
| comment | FUNCTION Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs (PubMed:12962325, PubMed:19061985, PubMed:23636399, PubMed:24120868). It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 (PubMed:24120868).SUBUNIT Component of the large ribosomal subunit (LSU). Part of the 5S RNP complex, which is a LSU subcomplex composed of the 5S RNA, RPL5 and RPL11 (PubMed:24120868, PubMed:37291423). Component of a hexameric 5S RNP precursor complex, composed of 5S RNA, RRS1, RPF2/BXDC1, RPL5, RPL11 and HEATR3; this complex acts as a precursor for ribosome assembly (PubMed:37291423). Interacts with isoform 1 of NVL in an ATP-dependent manner (PubMed:15469983). Interacts with RRP1B (PubMed:20926688). Interacts with IPO5, IPO7 and KPNB1; these interactions may be involved in RPL5 nuclear import for the assembly of ribosomal subunits (PubMed:9687515).INTERACTION Although RP5 is functional within the cytoplasm, the assembly of ribosomal subunits occurs in the nucleus. RPL5 nuclear import is mediated by IPO5/RanBP5, IPO7/RanBP7, KPNB1/importin-beta or TPNO1/Trn.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the universal ribosomal protein uL18 family. |
| description | recommendedName: fullName evidence="14"Large ribosomal subunit protein uL18 alternativeName: 60S ribosomal protein L5 |
| geneName | RPL5 MSTP030 |
| identifier | P46777 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Cytoplasm Diamond-Blackfan anemia Direct protein sequencing Disease variant Isopeptide bond Nucleus Phosphoprotein Proteomics identification Reference proteome Ribonucleoprotein Ribosomal protein RNA-binding rRNA-binding Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | RPL5 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8995092] ENSEMBL:ENSG00000122406 RPL5 [Homo sapiens] |
| secondaryIdentifier | RL5_HUMAN Q32LZ3 Q53HH6 Q9H3F4 |
| sequenceLength | 297 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:72482] RPL5 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P46777 RPL5 (72481)
