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Details on Person UniProt:P62750 RPL23A
| Class:Id | ReferenceGeneProduct:72431 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-156 added on Fri February 6 2015;initiator methionine:1 for 72431 removed on Fri Nov 03 2023;initiator methionine: for 72431 added on Fri Nov 03 2023;initiator methionine: for 72431 removed on Fri Aug 15 2025;initiator methionine:1 for 72431 added on Fri Aug 15 2025 |
| _displayName | UniProt:P62750 RPL23A |
| _timestamp | 2025-08-15 21:56:25 |
| chain | initiator methionine:1 chain:2-156 |
| checksum | 3980E77B47FAB70E |
| comment | FUNCTION Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). Binds a specific region on the 26S rRNA (PubMed:23636399, PubMed:32669547). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (PubMed:26203195).SUBUNIT Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). Interacts with LYAR and GNL2 (PubMed:26203195). Interacts with MDM2; this interaction may promote MDM2-mediated p53/TP53 polyubiquitination (PubMed:26203195). Directly interacts (via BIB domain) with IPO5, IPO7, KPNB1 and TNPO1; these interactions are involved in RPL23A nuclear import for the assembly of ribosomal subunits (PubMed:11682607, PubMed:9687515). Interacts with IPO8 (PubMed:11682607).INTERACTION Although RPL23A is functional within the cytoplasm, the assembly of ribosomal subunits occurs in the nucleus. RPL23A nuclear import is mediated by IPO5/RanBP5, IPO7/RanBP7, KPNB1/importin-beta or TPNO1/Trn.INDUCTION May be down-regulated by GNL2 (at protein level).DOMAIN The N-terminal beta-like import receptor binding (BIB) domain mediates interaction with IPO5, IPO7, KPNB1 and TNPO1.PTM N-terminus is methylated by METTL11A/NTM1.PTM Citrullinated by PADI4.SIMILARITY Belongs to the universal ribosomal protein uL23 family. |
| description | recommendedName: fullName evidence="9"Large ribosomal subunit protein uL23 alternativeName: 60S ribosomal protein L23a |
| geneName | RPL23A |
| identifier | P62750 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Citrullination Cytoplasm Isopeptide bond Methylation Nucleus Phosphoprotein Proteomics identification Reference proteome Ribonucleoprotein Ribosomal protein RNA-binding rRNA-binding Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | RPL23A |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8995089] ENSEMBL:ENSG00000198242 RPL23A [Homo sapiens] |
| secondaryIdentifier | RL23A_HUMAN B2R5B2 P29316 P39024 Q92774 |
| sequenceLength | 156 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:72432] RPL23A [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P62750 RPL23A (72431)
