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Details on Person UniProt:P40429 RPL13A
| Class:Id | ReferenceGeneProduct:72411 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-203 added on Fri February 6 2015;initiator methionine:1 for 72411 removed on Fri Nov 03 2023;initiator methionine: for 72411 added on Fri Nov 03 2023;initiator methionine: for 72411 removed on Fri Aug 15 2025;initiator methionine:1 for 72411 added on Fri Aug 15 2025 |
| _displayName | UniProt:P40429 RPL13A |
| _timestamp | 2025-08-15 21:02:54 |
| chain | initiator methionine:1 chain:2-203 |
| checksum | 3E80D0AB77A0D406 |
| comment | FUNCTION Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions (PubMed:14567916, PubMed:17218275, PubMed:23636399, PubMed:32669547). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094). Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (PubMed:23071094). In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex (PubMed:23071094). Involved in methylation of rRNA (PubMed:17921318).SUBUNIT Component of the 60S ribosome (PubMed:12962325, PubMed:14567916, PubMed:23636399, PubMed:32669547). Component of the GAIT complex (PubMed:15479637). Interacts with EIF4G1 (PubMed:17218275).SUBCELLULAR LOCATION Phosphorylation at Ser-77 upon interferon-gamma treatment in monocytes involves a DAPK1-DAPK3 kinase cascade and is causing release from the ribosome, association with the GAIT complex and subsequent involvement in transcript-selective translation inhibition.PTM Citrullinated by PADI4.SIMILARITY Belongs to the universal ribosomal protein uL13 family. |
| description | recommendedName: fullName evidence="13"Large ribosomal subunit protein uL13 alternativeName: 23 kDa highly basic protein alternativeName: 60S ribosomal protein L13a |
| geneName | RPL13A |
| identifier | P40429 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Citrullination Cytoplasm Direct protein sequencing Phosphoprotein Proteomics identification Reference proteome Ribonucleoprotein Ribosomal protein Translation regulation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | RPL13A |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8994467] ENSEMBL:ENSG00000142541 RPL13A [Homo sapiens] |
| secondaryIdentifier | RL13A_HUMAN A8K505 |
| sequenceLength | 203 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:72412] RPL13A [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:156829] p-RPL13A [cytosol] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:156834] phosphorylated residue at unknown position |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P40429 RPL13A (72411)
