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Details on Person UniProt:P05388 RPLP0
| Class:Id | ReferenceGeneProduct:72395 |
|---|---|
| _chainChangeLog | chain:1-317 added on Fri February 6 2015 |
| _displayName | UniProt:P05388 RPLP0 |
| _timestamp | 2024-11-03 19:43:11 |
| chain | chain:1-317 |
| checksum | 255AD25571C51199 |
| comment | FUNCTION Ribosomal protein P0 is the functional equivalent of E.coli protein L10.SUBUNIT P0 forms a pentameric complex by interaction with dimers of P1 and P2 (PubMed:3323886). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (PubMed:17289661). Interacts with APEX1 (PubMed:19188445). Interacts with FMR1 isoform 6 (PubMed:24658146).INTERACTION Localized in cytoplasmic mRNP granules containing untranslated mRNAs (PubMed:17289661, PubMed:19188445).ALTERNATIVE PRODUCTS Ubiquitinated at Lys-264 by RNF14 and RNF25 in response to ribosome collisions (ribosome stalling).SIMILARITY Belongs to the universal ribosomal protein uL10 family. |
| description | recommendedName: fullName evidence="9"Large ribosomal subunit protein uL10 alternativeName: 60S acidic ribosomal protein P0 alternativeName: 60S ribosomal protein L10E |
| geneName | RPLP0 |
| identifier | P05388 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cytoplasm Direct protein sequencing Isopeptide bond Nucleus Phosphoprotein Proteomics identification Reference proteome Ribonucleoprotein Ribosomal protein Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | RPLP0 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8950512] ENSEMBL:ENSG00000089157 RPLP0 [Homo sapiens] |
| secondaryIdentifier | RLA0_HUMAN Q3B7A4 Q9BVK4 |
| sequenceLength | 317 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8975303] UniProt:P05388-1 RPLP0 [Homo sapiens] [ReferenceIsoform:8975304] UniProt:P05388-2 RPLP0 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:72396] RPLP0 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8957673] RPLP0 [extracellular region] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P05388 RPLP0 (72395)
