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Details on Person UniProt:P62241 RPS8
| Class:Id | ReferenceGeneProduct:72384 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-208 added on Sat February 7 2015;initiator methionine:1 for 72384 removed on Fri Nov 03 2023;initiator methionine: for 72384 added on Fri Nov 03 2023;initiator methionine: for 72384 removed on Fri Aug 15 2025;initiator methionine:1 for 72384 added on Fri Aug 15 2025 |
| _displayName | UniProt:P62241 RPS8 |
| _timestamp | 2025-08-15 22:11:36 |
| chain | initiator methionine:1 chain:2-208 |
| checksum | 407FDF59171F7422 |
| comment | FUNCTION Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797).SUBUNIT Component of the small ribosomal subunit (PubMed:23636399). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (PubMed:17289661). Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3 (PubMed:34516797).INTERACTION Localized in cytoplasmic mRNP granules containing untranslated mRNAs.SIMILARITY Belongs to the eukaryotic ribosomal protein eS8 family. |
| description | recommendedName: fullName evidence="8"Small ribosomal subunit protein eS8 alternativeName: 40S ribosomal protein S8 |
| geneName | RPS8 OK/SW-cl.83 |
| identifier | P62241 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Cytoplasm Direct protein sequencing Isopeptide bond Lipoprotein Membrane Myristate Nucleus Phosphoprotein Proteomics identification Reference proteome Ribonucleoprotein Ribosomal protein Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | RPS8 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9003212] ENSEMBL:ENSG00000142937 RPS8 [Homo sapiens] |
| secondaryIdentifier | RS8_HUMAN P09058 Q6IRL7 |
| sequenceLength | 208 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:72385] RPS8 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:6791203] RPS8 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P62241 RPS8 (72384)
