Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:P62081 RPS7
| Class:Id | ReferenceGeneProduct:72382 |
|---|---|
| _chainChangeLog | chain:1-194 added on Sat February 7 2015 |
| _displayName | UniProt:P62081 RPS7 |
| _timestamp | 2024-11-03 19:53:48 |
| chain | chain:1-194 |
| checksum | E21089929CC061E9 |
| comment | FUNCTION Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Required for rRNA maturation (PubMed:19061985). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797).SUBUNIT Component of the small ribosomal subunit (PubMed:23636399). Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3 (PubMed:34516797). Binds IPO9 with high affinity (PubMed:11823430). Interacts with NEK6 (PubMed:20873783). Interacts with DESI2 (PubMed:28483520). Interacts with IPO5, IPO7 and KPNB1; these interactions may be involved in RPS7 nuclear import for the assembly of ribosomal subunits (PubMed:9687515).INTERACTION Although RPS7 is functional within the cytoplasm, the assembly of ribosomal subunits occurs in the nucleus. RPS7 nuclear import is mediated by IPO5/RanBP5, IPO7/RanBP7, KPNB1/importin-beta or TPNO1/Trn (PubMed:9687515). Colocalizes with NEK6 in the centrosome (PubMed:20873783).PTM Phosphorylated by NEK6.PTM Ubiquitinated. Deubiquitinated by DESI2, leading to its stabilization.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the eukaryotic ribosomal protein eS7 family. |
| description | recommendedName: fullName evidence="9"Small ribosomal subunit protein eS7 alternativeName: 40S ribosomal protein S7 |
| geneName | RPS7 |
| identifier | P62081 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Cytoplasm Cytoskeleton Diamond-Blackfan anemia Direct protein sequencing Isopeptide bond Nucleus Proteomics identification Reference proteome Ribonucleoprotein Ribosomal protein Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | RPS7 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8960147] ENSEMBL:ENSG00000171863 RPS7 [Homo sapiens] |
| secondaryIdentifier | RS7_HUMAN P23821 P24818 Q57Z92 Q6IPH1 |
| sequenceLength | 194 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:72383] RPS7 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:6790635] RPS7 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:8960708] RPS7 [extracellular region] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P62081 RPS7 (72382)
