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Details on Person UniProt:P61247 RPS3A
| Class:Id | ReferenceGeneProduct:72372 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-264 added on Sat February 7 2015;initiator methionine:1 for 72372 removed on Fri Nov 03 2023;initiator methionine: for 72372 added on Fri Nov 03 2023;initiator methionine: for 72372 removed on Fri Aug 15 2025;initiator methionine:1 for 72372 added on Fri Aug 15 2025 |
| _displayName | UniProt:P61247 RPS3A |
| _timestamp | 2025-08-15 22:04:04 |
| chain | initiator methionine:1 chain:2-264 |
| checksum | 000037AE195F7A9D |
| comment | FUNCTION Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). May play a role during erythropoiesis through regulation of transcription factor DDIT3 (By similarity).SUBUNIT Component of the small ribosomal subunit (PubMed:23636399). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:23636399). The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S) (PubMed:23636399). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (PubMed:17289661). Binds with high affinity to IPO4 (PubMed:11823430). Interacts with DDIT3. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3 (PubMed:34516797).INTERACTION Localized in cytoplasmic mRNP granules containing untranslated mRNAs.PTM ADP-ribosylated at Tyr-155 by PARP1 in presence of HPF1.SIMILARITY Belongs to the eukaryotic ribosomal protein eS1 family. |
| description | recommendedName: fullName evidence="2 10"Small ribosomal subunit protein eS1 alternativeName: 40S ribosomal protein S3a alternativeName: v-fos transformation effector protein shortName: Fte-1 |
| geneName | RPS3A FTE1 MFTL |
| identifier | P61247 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation ADP-ribosylation Cytoplasm Differentiation Direct protein sequencing Isopeptide bond Nucleus Phosphoprotein Proteomics identification Reference proteome Ribonucleoprotein Ribosomal protein Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | RPS3A |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8988640] ENSEMBL:ENSG00000145425 RPS3A [Homo sapiens] |
| secondaryIdentifier | RS3A_HUMAN B2R4D4 D3DP05 P33443 P49241 |
| sequenceLength | 264 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:72373] RPS3A [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:6791182] RPS3A [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P61247 RPS3A (72372)
