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Details on Person UniProt:P42677 RPS27
| Class:Id | ReferenceGeneProduct:72360 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-84 added on Fri February 6 2015;initiator methionine:1 for 72360 removed on Fri Nov 03 2023;initiator methionine: for 72360 added on Fri Nov 03 2023;initiator methionine: for 72360 removed on Fri Aug 15 2025;initiator methionine:1 for 72360 added on Fri Aug 15 2025 |
| _displayName | UniProt:P42677 RPS27 |
| _timestamp | 2025-08-15 21:33:41 |
| chain | initiator methionine:1 chain:2-84 |
| checksum | 242C4466AC8A8900 |
| comment | FUNCTION Component of the small ribosomal subunit (PubMed:23636399, PubMed:8706699). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Required for proper rRNA processing and maturation of 18S rRNAs (PubMed:25424902). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797).COFACTOR Binds 1 zinc ion per subunit.SUBUNIT Component of the small ribosomal subunit (Probable) (PubMed:23636399). Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3 (PubMed:34516797).INTERACTION Expressed in a wide variety of actively proliferating cells and tumor tissues.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the eukaryotic ribosomal protein eS27 family.CAUTION Was originally (PubMed:8407955) thought to be a protein that could have played a role as a potentially important mediator of cellular proliferative responses to various growth factors and other environmental signals. Capable of specific binding to a cAMP response element in DNA. |
| description | recommendedName: fullName evidence="8"Small ribosomal subunit protein eS27 alternativeName: 40S ribosomal protein S27 alternativeName: Metallopan-stimulin 1 shortName: MPS-1 |
| geneName | RPS27 MPS1 |
| identifier | P42677 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cytoplasm Diamond-Blackfan anemia Direct protein sequencing Metal-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Ribonucleoprotein Ribosomal protein Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | RPS27 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9004943] ENSEMBL:ENSG00000177954 RPS27 [Homo sapiens] |
| secondaryIdentifier | RS27_HUMAN Q5T4L6 |
| sequenceLength | 84 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:72361] RPS27 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:6791190] RPS27 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P42677 RPS27 (72360)
