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Details on Person UniProt:P62266 RPS23
| Class:Id | ReferenceGeneProduct:72352 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-143 added on Sat February 7 2015;initiator methionine:1 for 72352 removed on Fri Nov 03 2023;initiator methionine: for 72352 added on Fri Nov 03 2023;initiator methionine: for 72352 removed on Fri Aug 15 2025;initiator methionine:1 for 72352 added on Fri Aug 15 2025 |
| _displayName | UniProt:P62266 RPS23 |
| _timestamp | 2025-08-15 21:33:41 |
| chain | initiator methionine:1 chain:2-143 |
| checksum | 8417A48B8CF0A8E5 |
| comment | FUNCTION Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:28257692). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (PubMed:23636399, PubMed:25901680, PubMed:25957688). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (PubMed:23636399, PubMed:25901680, PubMed:25957688). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:23636399, PubMed:25901680, PubMed:25957688). Plays an important role in translational accuracy (PubMed:28257692). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797).SUBUNIT Component of the 40S small ribosomal subunit (PubMed:23636399, PubMed:25901680, PubMed:25957688). Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3 (PubMed:34516797).INTERACTION Detected on cytosolic polysomes (PubMed:25957688). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity).PTM Hydroxylation at Pro-62 affects translation termination efficiency.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the universal ribosomal protein uS12 family. |
| description | recommendedName: fullName evidence="12"Small ribosomal subunit protein uS12 alternativeName: 40S ribosomal protein S23 |
| geneName | RPS23 |
| identifier | P62266 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Cytoplasm Deafness Direct protein sequencing Disease variant Dwarfism Endoplasmic reticulum Hydroxylation Isopeptide bond Nucleus Proteomics identification Reference proteome Ribonucleoprotein Ribosomal protein Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | RPS23 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8993281] ENSEMBL:ENSG00000186468 RPS23 [Homo sapiens] |
| secondaryIdentifier | RS23_HUMAN P39028 Q6IB08 |
| sequenceLength | 143 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:72353] RPS23 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:6791209] RPS23 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9630773] 3OHP62-RPS23 [nucleoplasm] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:9630759] 3-hydroxy-L-proline at 62 |
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No pathways have been reviewed or authored by UniProt:P62266 RPS23 (72352)
