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Details on Person UniProt:P60866 RPS20
| Class:Id | ReferenceGeneProduct:72348 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-119 added on Sat February 7 2015;initiator methionine:1 for 72348 removed on Fri Nov 03 2023;initiator methionine: for 72348 added on Fri Nov 03 2023;initiator methionine: for 72348 removed on Fri Aug 15 2025;initiator methionine:1 for 72348 added on Fri Aug 15 2025 |
| _displayName | UniProt:P60866 RPS20 |
| _timestamp | 2025-08-15 22:11:33 |
| chain | initiator methionine:1 chain:2-119 |
| checksum | 8802DF7894ADDF94 |
| comment | FUNCTION Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399).SUBUNIT Component of the 40S small ribosomal subunit.INTERACTION Polyubiquitinated by ZNF598 via 'Lys-63'-linked ubiquitin chains when a ribosome has stalled, initiating the ribosome quality control (RQC) pathway to degrade the potentially detrimental aberrant nascent polypeptide (PubMed:28065601, PubMed:28132843, PubMed:28685749, PubMed:32011234, PubMed:36302773). Deubiquitinated by OTUD3 and USP21, antagonizing ZNF598 activity (PubMed:32011234).PTM Ufmylated by UFL1.SIMILARITY Belongs to the universal ribosomal protein uS10 family. |
| description | recommendedName: fullName evidence="10"Small ribosomal subunit protein uS10 alternativeName: 40S ribosomal protein S20 |
| geneName | RPS20 |
| identifier | P60866 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Cytoplasm Direct protein sequencing Isopeptide bond Phosphoprotein Proteomics identification Reference proteome Ribonucleoprotein Ribosomal protein Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | RPS20 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8957912] ENSEMBL:ENSG00000008988 RPS20 [Homo sapiens] |
| secondaryIdentifier | RS20_HUMAN B2R4F4 B4DW28 P17075 Q5M8S9 |
| sequenceLength | 119 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8974880] UniProt:P60866-1 RPS20 [Homo sapiens] [ReferenceIsoform:8974881] UniProt:P60866-2 RPS20 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:72349] RPS20 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:6798727] RPS20 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:8957681] RPS20 [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:9948312] K63polyUb-K8-RPS20 [cytosol] [Homo sapiens] |
| (referenceSequence) | [GroupModifiedResidue:9948296] ubiquitinylated lysine (K63polyUb [cytosol]) at 8 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P60866 RPS20 (72348)
