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Details on Person UniProt:P62244 RPS15A
| Class:Id | ReferenceGeneProduct:72344 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-130 added on Fri February 6 2015;initiator methionine:1 for 72344 removed on Fri Nov 03 2023;initiator methionine: for 72344 added on Fri Nov 03 2023;initiator methionine: for 72344 removed on Fri Aug 15 2025;initiator methionine:1 for 72344 added on Fri Aug 15 2025 |
| _displayName | UniProt:P62244 RPS15A |
| _timestamp | 2025-08-15 21:03:03 |
| chain | initiator methionine:1 chain:2-130 |
| checksum | D4AC1E8864E3A184 |
| comment | FUNCTION Component of the small ribosomal subunit (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Required for proper erythropoiesis (PubMed:27909223).SUBUNIT Component of the 40S ribosomal subunit. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3 (PubMed:34516797).INTERACTION The disease may be caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the universal ribosomal protein uS8 family. |
| description | recommendedName: fullName evidence="6"Small ribosomal subunit protein uS8 alternativeName: 40S ribosomal protein S15a |
| geneName | RPS15A OK/SW-cl.82 |
| identifier | P62244 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cytoplasm Diamond-Blackfan anemia Direct protein sequencing Nucleus Proteomics identification Reference proteome Ribonucleoprotein Ribosomal protein |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | RPS15A |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8992113] ENSEMBL:ENSG00000134419 RPS15A [Homo sapiens] |
| secondaryIdentifier | RS15A_HUMAN P39027 P39031 Q3MHD9 Q8C023 Q9BV24 |
| sequenceLength | 130 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:72345] RPS15A [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:6791191] RPS15A [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P62244 RPS15A (72344)
