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Details on Person UniProt:P25398 RPS12
| Class:Id | ReferenceGeneProduct:72328 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-132 added on Fri February 6 2015;initiator methionine:1 for 72328 removed on Fri Nov 03 2023;initiator methionine: for 72328 added on Fri Nov 03 2023;initiator methionine: for 72328 removed on Fri Aug 15 2025;initiator methionine:1 for 72328 added on Fri Aug 15 2025 |
| _displayName | UniProt:P25398 RPS12 |
| _timestamp | 2025-08-15 22:04:02 |
| chain | initiator methionine:1 chain:2-132 |
| checksum | 45AD1274D55FFA25 |
| comment | FUNCTION Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Subunit of the 40S ribosomal complex (By similarity).SUBUNIT Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3 (PubMed:23636399, PubMed:34516797). Subunit of the 40S ribosomal complex (By similarity).INTERACTION Belongs to the eukaryotic ribosomal protein eS12 family. |
| description | recommendedName: fullName evidence="6"Small ribosomal subunit protein eS12 alternativeName: 40S ribosomal protein S12 |
| geneName | RPS12 |
| identifier | P25398 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Cytoplasm Direct protein sequencing Nucleus Proteomics identification Reference proteome Ribonucleoprotein Ribosomal protein |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | RPS12 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8958516] ENSEMBL:ENSG00000112306 RPS12 [Homo sapiens] |
| secondaryIdentifier | RS12_HUMAN Q76M58 |
| sequenceLength | 132 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:72329] RPS12 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:6798715] RPS12 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:8958283] RPS12 [extracellular region] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P25398 RPS12 (72328)
