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Details on Person UniProt:P46783 RPS10
| Class:Id | ReferenceGeneProduct:72324 |
|---|---|
| _chainChangeLog | chain:1-165 added on Sat February 7 2015 |
| _displayName | UniProt:P46783 RPS10 |
| _timestamp | 2024-11-03 19:43:16 |
| chain | chain:1-165 |
| checksum | 64106DFCD97AABA3 |
| comment | FUNCTION Component of the 40S ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399).SUBUNIT Component of the small ribosomal subunit (PubMed:23636399). The methylated form interacts with NPM1 (PubMed:20159986).INTERACTION Localized in the granular component (GC) region of the nucleolus. Methylation is required for its localization in the GC region. Colocalizes with NPS1 in the GC region of the nucleolus.PTM Methylated by PRMT5. Methylation is necessary for its interaction with NPS1, its localization in the granular component (GC) region of the nucleolus, for the proper assembly of ribosomes, protein synthesis and optimal cell proliferation.PTM Monoubiquitinated by ZNF598 when a ribosome has stalled during translation of poly(A) sequences, leading to preclude synthesis of a long poly-lysine tail and initiate the ribosome quality control (RQC) pathway to degrade the potentially detrimental aberrant nascent polypeptide (PubMed:28065601, PubMed:28132843, PubMed:28685749, PubMed:32011234, PubMed:36302773). Deubiquitinated by OTUD3 and USP21, antagonizing ZNF598 activity (PubMed:32011234). Deubiquitinated by OTUD1, antagonizing ZNF598 activity and stimulating formation of polysomes: deubiquitination by OTUD1 promotes stability and translation of a subset mRNAs with a high abundance of rare codons can limit the translation rate (PubMed:36445135). Deubiquitinated by USP10 (PubMed:31981475).DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the eukaryotic ribosomal protein eS10 family. |
| description | recommendedName: fullName evidence="13"Small ribosomal subunit protein eS10 alternativeName: 40S ribosomal protein S10 |
| geneName | RPS10 |
| identifier | P46783 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cytoplasm Diamond-Blackfan anemia Direct protein sequencing Isopeptide bond Methylation Nucleus Phosphoprotein Proteomics identification Reference proteome Ribonucleoprotein Ribosomal protein Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | RPS10 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8996850] ENSEMBL:ENSG00000124614 RPS10 [Homo sapiens] |
| secondaryIdentifier | RS10_HUMAN B2R4E3 Q5TZC0 |
| sequenceLength | 165 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:72325] RPS10 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:6798733] RPS10 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9948298] K63polyUb-K138,K139-RPS10 [cytosol] [Homo sapiens] |
| (referenceSequence) | [GroupModifiedResidue:9948307] ubiquitinylated lysine (K63polyUb [cytosol]) at 138 [GroupModifiedResidue:9948323] ubiquitinylated lysine (K63polyUb [cytosol]) at 139 |
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No pathways have been reviewed or authored by UniProt:P46783 RPS10 (72324)
