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Details on Person UniProt:O43143 DHX15

Class:IdReferenceGeneProduct:72291
_chainChangeLogchain:1-795 added on Fri February 6 2015
_displayNameUniProt:O43143 DHX15
_timestamp2025-02-21 18:55:51
chainchain:1-795
checksum9A21FBE0051CCAA9
commentFUNCTION RNA helicase involved in mRNA processing and antiviral innate immunity (PubMed:19103666, PubMed:19432882, PubMed:24782566, PubMed:24990078, PubMed:32179686, PubMed:34161762). Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA (PubMed:19103666). In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns (PubMed:19103666). Plays a key role in antiviral innate immunity by promoting both MAVS-dependent signaling and NLRP6 inflammasome (PubMed:24782566, PubMed:24990078, PubMed:34161762). Acts as an RNA virus sensor: recognizes and binds viral double stranded RNA (dsRNA) and activates the MAVS-dependent signaling to produce interferon-beta and interferon lambda-3 (IFNL3) (PubMed:24782566, PubMed:24990078, PubMed:34161762). Involved in intestinal antiviral innate immunity together with NLRP6: recognizes and binds viral dsRNA and promotes activation of the NLRP6 inflammasome in intestinal epithelial cells to restrict infection by enteric viruses (PubMed:34161762). The NLRP6 inflammasome acts by promoting maturation and secretion of IL18 in the extracellular milieu (PubMed:34161762). Also involved in antibacterial innate immunity by promoting Wnt-induced antimicrobial protein expression in Paneth cells (By similarity).CATALYTIC ACTIVITY ATP + H2O = ADP + phosphate + H(+)ACTIVITY REGULATION ATPase activity is enhanced upon binding to G-patch domain-containing proteins (PubMed:32179686). G-patch domain-containing proteins act like a brace that tethers mobile sections of DHX15 together, stabilizing a functional conformation with high RNA affinity, thereby promoting the ATPase activity (PubMed:32179686).SUBUNIT Component of the U11/U12 snRNPs that are part of the U12-type spliceosome (PubMed:15146077). Identified in the Intron Large spliceosome complex (IL, also named intron lariat spliceosome), a post-mRNA release spliceosomal complex containing the excised intron, U2, U5 and U6 snRNPs, and splicing factors; the association may be transient (PubMed:19103666, PubMed:30728453). The IL complex exists in two distinct conformations, one with the DHX15 (ILS2) and one without (ILS1) (PubMed:30728453). Interacts with TFIP11 (via G-patch domain); indicative for a recruitment to the IL complex (PubMed:19103666). Interacts with SSB/La (PubMed:12458796). Interacts with GPATCH2 (via G-patch domain); promoting the RNA helicase activity (PubMed:19432882). Interacts with NKRF (via G-patch domain); promoting the RNA helicase activity (PubMed:32179686). Interacts with NLRP6 (PubMed:34161762).INTERACTION Ubiquitous.SIMILARITY Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.
descriptionrecommendedName: fullName evidence="18"ATP-dependent RNA helicase DHX15 ecNumber evidence="8 12"3.6.4.13 alternativeName: ATP-dependent RNA helicase #46 alternativeName: DEAH box protein 15 alternativeName: fullName evidence="15"Splicing factor Prp43 shortName evidence="15"hPrp43
geneNameDHX15
DBP1
DDX15
identifierO43143
isSequenceChangedFALSE
keyword3D-structure
Acetylation
ATP-binding
Helicase
Hydrolase
Immunity
Innate immunity
Isopeptide bond
mRNA processing
mRNA splicing
Nucleotide-binding
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
RNA-binding
Ubl conjugation
modified[InstanceEdit:9836292] Weiser, Joel, 2023-05-25
[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
[InstanceEdit:9917590] Weiser, Joel, 2024-08-09
[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
[InstanceEdit:9939033] Weiser, Joel, 2025-02-21
nameDHX15
referenceDatabase[ReferenceDatabase:2] UniProt
referenceGene[ReferenceDNASequence:8960109] ENSEMBL:ENSG00000109606 DHX15 [Homo sapiens]
secondaryIdentifierDHX15_HUMAN
Q9NQT7
sequenceLength795
species[Species:48887] Homo sapiens
(referenceEntity)[EntityWithAccessionedSequence:5688097] DHX15 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:8960460] DHX15 [extracellular region] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:O43143 DHX15 (72291)
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