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Details on Person UniProt:Q969L4 LSM10
| Class:Id | ReferenceGeneProduct:72283 |
|---|---|
| _chainChangeLog | chain:1-123 added on Sat February 7 2015 |
| _displayName | UniProt:Q969L4 LSM10 |
| _timestamp | 2024-11-03 19:37:22 |
| chain | chain:1-123 |
| checksum | B994B1DC6776BB02 |
| comment | FUNCTION Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed. Required for cell cycle progression from G1 to S phases. Binds specifically to U7 snRNA. Binds to the downstream cleavage product (DCP) of histone pre-mRNA in a U7 snRNP dependent manner.SUBUNIT Component of the heptameric ring U7 snRNP complex, or U7 Sm protein core complex, at least composed of LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF, SNRPG and U7 snRNA. Formation of the U7 snRNP is an ATP-dependent process mediated by a specialized SMN complex containing at least the Sm protein core complex and additionally, the U7-specific LSM10 and LSM11 proteins. Interacts with CLNS1A and SMN.INTERACTION Not methylated. Methylation is not necessary for interaction with SMN.SIMILARITY Belongs to the snRNP Sm proteins family. |
| description | recommendedName: U7 snRNA-associated Sm-like protein LSm10 |
| geneName | LSM10 |
| identifier | Q969L4 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure mRNA processing mRNA splicing Nucleus Proteomics identification Reference proteome Ribonucleoprotein RNA-binding |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | LSM10 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8997803] ENSEMBL:ENSG00000181817 LSM10 [Homo sapiens] |
| secondaryIdentifier | LSM10_HUMAN |
| sequenceLength | 123 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:58738] LSM10 [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q969L4 LSM10 (72283)
