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Details on Person UniProt:Q9BWT3 PAPOLG
| Class:Id | ReferenceGeneProduct:72257 |
|---|---|
| _chainChangeLog | chain:1-736 added on Fri February 6 2015 |
| _displayName | UniProt:Q9BWT3 PAPOLG |
| _timestamp | 2025-02-21 20:02:16 |
| chain | chain:1-736 |
| checksum | B0F6F217AA36E552 |
| comment | FUNCTION Responsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA.CATALYTIC ACTIVITY RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphateCOFACTOR Binds 2 magnesium ions. Also active with manganese.BIOPHYSICOCHEMICAL PROPERTIES Expressed predominantly in testis, and weakly in other tissues. Overexpressed in several tumors.SIMILARITY Belongs to the poly(A) polymerase family.SEQUENCE CAUTION Truncated N-terminus. |
| description | recommendedName: Poly(A) polymerase gamma shortName: PAP-gamma ecNumber evidence="3 4 5"2.7.7.19 alternativeName: Neo-poly(A) polymerase shortName evidence="7"Neo-PAP alternativeName: Polynucleotide adenylyltransferase gamma alternativeName: SRP RNA 3'-adenylating enzyme alternativeName: Signal recognition particle RNA-adenylating enzyme shortName: SRP RNA-adenylating enzyme |
| geneName | PAPOLG PAP2 PAPG |
| identifier | Q9BWT3 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing ATP-binding Direct protein sequencing Magnesium Manganese Metal-binding mRNA processing Nucleotide-binding Nucleus Phosphoprotein Proteomics identification Reference proteome RNA-binding Transferase |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | PAPOLG |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8988564] ENSEMBL:ENSG00000115421 PAPOLG [Homo sapiens] |
| secondaryIdentifier | PAPOG_HUMAN B2RBH4 Q59G05 Q969N1 Q9H8L2 Q9HAD0 |
| sequenceLength | 736 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8966683] UniProt:Q9BWT3-1 PAPOLG [Homo sapiens] [ReferenceIsoform:8966684] UniProt:Q9BWT3-2 PAPOLG [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:9934098] PAPOLG [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9BWT3 PAPOLG (72257)
