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Details on Person UniProt:Q9Y2L1 DIS3
| Class:Id | ReferenceGeneProduct:72245 |
|---|---|
| _chainChangeLog | chain:1-958 added on Sat February 7 2015 |
| _displayName | UniProt:Q9Y2L1 DIS3 |
| _timestamp | 2026-02-20 21:34:05 |
| chain | chain:1-958 |
| checksum | 92336BA0D06247FE |
| comment | FUNCTION Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities.COFACTOR Component of the RNA exosome complex; within the complex interacts with EXOSC4, EXOSC7 and EXOSC9 of the exosome core complex (Exo-9) (PubMed:29906447, PubMed:30047866). The catalytically inactive RNA exosome core complex (Exo-9) associates with the catalytic subunit EXOSC10/RRP6 (PubMed:20531389, PubMed:29906447). Exo-9 may associate with DIS3 to form the nucleolar exosome complex, or DIS3L to form the cytoplasmic exosome complex (PubMed:20531389, PubMed:29906447). Exo-9 is formed by a hexameric base ring consisting of the heterodimers EXOSC4-EXOSC9, EXOSC5-EXOSC8 and EXOSC6-EXOSC7, and a cap ring consisting of EXOSC1, EXOSC2 and EXOSC3; DIS3 associates with the base ring of Exo-9 (PubMed:20531389, PubMed:30047866). The RNA exosome complex associates with cofactors C1D/RRP47, MPHOSPH6/MPP6 and MTREX/MTR4 (PubMed:30047866). Interacts with DHX34; the interaction is RNA-independent (PubMed:25220460).SUBCELLULAR LOCATION Predominantly located in the nucleus (PubMed:20531386). According to PubMed:12429849, found in the nucleolus (PubMed:12429849). According to PubMed:20531386, excluded from nucleolus supporting the existence of a nucleolar RNA exosome complex devoid of DIS3 (PubMed:20531386).ALTERNATIVE PRODUCTS Widely expressed.MISCELLANEOUS The association of DIS3 with the RNA exosome complex appears to be weak explaining its absence in some complex purifications.SIMILARITY Belongs to the RNR ribonuclease family.SEQUENCE CAUTION Extended N-terminus. |
| description | recommendedName: Exosome complex exonuclease RRP44 ecNumber: 3.1.13.- ecNumber: 3.1.26.- alternativeName: Protein DIS3 homolog alternativeName: Ribosomal RNA-processing protein 44 |
| geneName | DIS3 KIAA1008 RRP44 |
| identifier | Q9Y2L1 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Cytoplasm Endonuclease Exonuclease Exosome Hydrolase Magnesium Manganese Nuclease Nucleus Phosphoprotein Proteomics identification Reference proteome RNA-binding rRNA processing |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | DIS3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8989196] ENSEMBL:ENSG00000083520 DIS3 [Homo sapiens] |
| secondaryIdentifier | RRP44_HUMAN A6NI21 B2RBL2 Q5W0P7 Q5W0P8 Q658Z7 Q7Z481 Q8WWI2 Q9UG36 |
| sequenceLength | 958 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:246512] UniProt:Q9Y2L1-2 DIS3 [Homo sapiens] [ReferenceIsoform:415959] UniProt:Q9Y2L1-1 DIS3 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:429935] DIS3 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:6791517] DIS3 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9935841] DIS3 [nucleolus] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9Y2L1 DIS3 (72245)
