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Details on Person UniProt:O75818 RPP40
| Class:Id | ReferenceGeneProduct:72221 |
|---|---|
| _chainChangeLog | chain:1-363 added on Fri February 6 2015 |
| _displayName | UniProt:O75818 RPP40 |
| _timestamp | 2024-11-03 20:16:25 |
| chain | chain:1-363 |
| checksum | 9B4495BA6CD40E79 |
| comment | FUNCTION Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:30454648, PubMed:9630247). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465).SUBUNIT Component of nuclear RNase P and RNase MRP ribonucleoproteins (PubMed:16723659, PubMed:28115465, PubMed:30454648, PubMed:9630247). RNase P consists of a catalytic RNA moiety and about 10 protein subunits; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40 (PubMed:16723659, PubMed:30454648, PubMed:9630247). Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA (PubMed:30454648). Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5 (PubMed:16723659, PubMed:28115465). |
| description | recommendedName: Ribonuclease P protein subunit p40 shortName: RNaseP protein p40 alternativeName: RNase P subunit 1 |
| geneName | RPP40 RNASEP1 |
| identifier | O75818 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Direct protein sequencing Nucleus Proteomics identification Reference proteome RNA-binding rRNA processing tRNA processing |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | RPP40 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9000287] ENSEMBL:ENSG00000124787 RPP40 [Homo sapiens] |
| secondaryIdentifier | RPP40_HUMAN Q5VX97 Q8WVK8 |
| sequenceLength | 363 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:424368] UniProt:O75818-1 RPP40 [Homo sapiens] [ReferenceIsoform:424369] UniProt:O75818-2 RPP40 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:5696801] RPP40 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O75818 RPP40 (72221)
