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Details on Person UniProt:P78345 RPP38

Class:IdReferenceGeneProduct:72220
_chainChangeLoginitiator methionine:1 added on Sat February 7 2015;chain:2-283 added on Sat February 7 2015;initiator methionine:1 for 72220 removed on Fri Nov 03 2023;initiator methionine: for 72220 added on Fri Nov 03 2023;initiator methionine: for 72220 removed on Fri Aug 15 2025;initiator methionine:1 for 72220 added on Fri Aug 15 2025
_displayNameUniProt:P78345 RPP38
_timestamp2025-08-15 21:33:38
chaininitiator methionine:1
chain:2-283
checksum233F3397DBDE4F18
commentFUNCTION Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:10444065, PubMed:30454648, PubMed:9037013, PubMed:9630247). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465).SUBUNIT Component of nuclear RNase P and RNase MRP ribonucleoproteins (PubMed:10444065, PubMed:16723659, PubMed:30454648, PubMed:9037013, PubMed:9630247). RNase P consists of a catalytic RNA moiety and about 10 protein subunits; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40 (PubMed:10444065, PubMed:16723659, PubMed:30454648, PubMed:9037013, PubMed:9630247). Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA (PubMed:30454648). Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5 (PubMed:16723659, PubMed:28115465).INTERACTION Autoantibodies against RPP38 are found in sera from scleroderma patients.SIMILARITY Belongs to the eukaryotic ribosomal protein eL8 family.
descriptionrecommendedName: Ribonuclease P protein subunit p38 shortName: RNaseP protein p38
geneNameRPP38
identifierP78345
isSequenceChangedFALSE
keyword3D-structure
Acetylation
Direct protein sequencing
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
RNA-binding
rRNA processing
tRNA processing
modified[InstanceEdit:9836292] Weiser, Joel, 2023-05-25
[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
[InstanceEdit:9917590] Weiser, Joel, 2024-08-09
[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
[InstanceEdit:9963647] Weiser, Joel, 2025-08-15
nameRPP38
referenceDatabase[ReferenceDatabase:2] UniProt
referenceGene[ReferenceDNASequence:8996232] ENSEMBL:ENSG00000152464 RPP38 [Homo sapiens]
secondaryIdentifierRPP38_HUMAN
B3KPY0
D3DRT8
Q53F71
Q8NHS8
sequenceLength283
species[Species:48887] Homo sapiens
(referenceEntity)[EntityWithAccessionedSequence:5696791] RPP38 [nucleoplasm] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:P78345 RPP38 (72220)
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