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Details on Person UniProt:O95059 RPP14
| Class:Id | ReferenceGeneProduct:72213 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-124 added on Sat February 7 2015;initiator methionine:1 for 72213 removed on Fri Nov 03 2023;initiator methionine: for 72213 added on Fri Nov 03 2023;initiator methionine: for 72213 removed on Fri Aug 15 2025;initiator methionine:1 for 72213 added on Fri Aug 15 2025 |
| _displayName | UniProt:O95059 RPP14 |
| _timestamp | 2025-08-15 21:10:46 |
| chain | initiator methionine:1 chain:2-124 |
| checksum | 10AF6C947785DD90 |
| comment | FUNCTION Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.SUBUNIT RNase P consists of a catalytic RNA moiety and about 10 protein subunits; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40 (PubMed:10024167, PubMed:16723659, PubMed:30454648). Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA (PubMed:30454648).INTERACTION This protein is produced by a bicistronic gene which also produces the HTD2 protein from an overlapping reading frame.SIMILARITY Belongs to the eukaryotic/archaeal RNase P protein component 2 family. |
| description | recommendedName: Ribonuclease P protein subunit p14 |
| geneName | RPP14 |
| identifier | O95059 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Direct protein sequencing Nucleus Proteomics identification Reference proteome RNA-binding tRNA processing |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | RPP14 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9001414] ENSEMBL:ENSG00000163684 RPP14 [Homo sapiens] |
| secondaryIdentifier | RPP14_HUMAN Q53X97 |
| sequenceLength | 124 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:5696794] RPP14 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O95059 RPP14 (72213)
