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Details on Person The best characterized case of C to U editing is in the inte...
| Class:Id | Summation:72201 |
|---|---|
| _displayName | The best characterized case of C to U editing is in the inte... |
| _timestamp | 2014-05-28 04:52:30 |
| modified | [InstanceEdit:75078] Joshi-Tope, G, 2003-08-22 11:27:00 [InstanceEdit:77603] Gopinathrao, G, 2003-11-10 10:16:53 [InstanceEdit:83523] Gopinathrao, G, 2003-11-14 11:35:01 [InstanceEdit:83675] Gopinathrao, G, 2003-11-24 12:41:17 [InstanceEdit:83817] Gopinathrao, G, 2003-11-30 18:34:56 [InstanceEdit:5577005] Matthews, Lisa, 2014-05-28 |
| text | The best characterized case of C to U editing is in the intestinal apolipoprotein B transcript, where the editing event creates a premature translation stop codon and consequently leads to a shorter form of the protein. In the liver, C to U editing is important in the expression of specific isoforms of the apolipoprotein B enzyme. ApoB mRNA editing is a posttranscriptional, nuclear process that can be initiated after splicing, at the time of polyadenylation and is completed by the time pre-mRNA matures fully (reviewed by Blanc and Davidson, 2003). This editing event is a simple hydrolytic cytidine deamination to uridine, and is carried out by the Apobec-1 enzyme, along with the Apobec-1 complementing factor, ACF. The editing of apo-B mRNA involves the site-specific deamination of (C6666 to U), which converts codon 2153 from a glutamine codon, CAA, to a premature stop codon, UAA. As ACF is distributed in a variety of tissues, and these genes contain multiple family members, it is possible that editing events in additional targets will be found. The cis-acting regulatory elements for C to U editing include: 22 nt editing site within ApoB mRNA, 5' tripartite motif with an enhancer element adjacent to the target cytidine, a spacer element and mooring sequence both 3' to the cytidine (reviewed by Smith et al., 1997). |
| (summation) | [Pathway:72200] mRNA Editing: C to U Conversion [Homo sapiens] |
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No pathways have been reviewed or authored by The best characterized case of C to U editing is in the inte... (72201)
