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Details on Person Internal Methylation of mRNA

Class:Id	Reaction:72095
_displayName	Internal Methylation of mRNA
_doRelease	TRUE
_timestamp	2016-11-10 00:54:46
catalystActivity	[CatalystActivity:72094] mRNA m(6)A methyltransferase activity of mRNA (N6-adenosine)-methyltransferase [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9643886] mRNA (N6-adenosine)-methyltransferase activity of mRNA (N6-adenosine)-methyltransferase [nucleoplasm] A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:72076] Krainer, AR, 2003-06-05 08:30:23
edited	[InstanceEdit:165073] Joshi-Tope, G, 0000-00-00 00:00:00
input	[Complex:77089] capped pre-mRNA:CBC:RNA Pol II (phosphorylated) complex [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:72096] Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase. [LiteratureReference:6789442] A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation [LiteratureReference:6789452] Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase [LiteratureReference:6789470] Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites
modified	[InstanceEdit:76041] Joshi-Tope, G, 2003-09-22 03:11:56 [InstanceEdit:77504] Joshi-Tope, G, 2003-10-30 01:32:00 [InstanceEdit:77583] Joshi-Tope, G, 2003-11-04 03:13:57 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:2671734] D'Eustachio, P, 2012-11-23 [InstanceEdit:6789476] May, Bruce, 2015-07-31 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Internal Methylation of mRNA
output	[Complex:71954] capped, methylated pre-mRNA:CBC Complex [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:77095] Recognition and binding of the mRNA cap by the cap-binding complex [Homo sapiens] [Reaction:77090] Methylation of GMP-cap by RNA Methyltransferase [Homo sapiens] [Reaction:77094] Formation of cap binding complex (CBC) [Homo sapiens]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358920] R-HSA-72095.5
summation	[Summation:72102] In addition to the methylation of the 5'-cap, there is methy...
(hasEvent)	[Pathway:72203] Processing of Capped Intron-Containing Pre-mRNA [Homo sapiens]
(inferredFrom)	[Reaction:1113108] Internal Methylation of mRNA [Oryza sativa]
(orthologousEvent)	[Reaction:1113108] Internal Methylation of mRNA [Oryza sativa]
(updatedInstance)	[_UpdateTracker:9784479] Update Tracker - [Reaction:72095] Internal Methylation of mRNA - v54:[addLiteratureReference]
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