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Details on Person UniProt:O60942 RNGTT

Class:Id	ReferenceGeneProduct:72080
_chainChangeLog	chain:1-597 added on Sat February 7 2015
_displayName	UniProt:O60942 RNGTT
_timestamp	2025-02-21 18:58:41
chain	chain:1-597
checksum	51CEEC1B190603DE
comment	FUNCTION Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.CATALYTIC ACTIVITY a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + phosphate + H(+)CATALYTIC ACTIVITY a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + diphosphateSUBUNIT Interacts with POLR2A (via C-terminus); this enhances guanylyltransferase activity. Binds (via GTase domain) to the elongating phosphorylated form of RNA polymerase II; can form direct interactions with the phosphorylated POLR2A C-terminal domain and indirect interactions via bound RNA (By similarity). Interacts with SUPT5H and RNMT. Interacts with HIV-1 Tat.SUBUNIT (Microbial infection) Interacts with HIV-1 Tat.INTERACTION Isoform 1 and isoform 4 (at a lesser extent) are expressed in cerebrum, cerebellum, thyroid, lung, heart, liver, kidney, spleen, large intestine, testis, skin and muscle.MISCELLANEOUS Isoform 2 to isoform 4 lack mRNA 5'-guanylyltransferase activity due to disruptions of the GTase domain.SIMILARITY In the N-terminal section; belongs to the non-receptor class of the protein-tyrosine phosphatase family.SIMILARITY In the C-terminal section; belongs to the eukaryotic GTase family.
description	recommendedName: mRNA-capping enzyme alternativeName: HCAP1 alternativeName: HCE domain recommendedName: mRNA 5'-triphosphate monophosphatase ecNumber evidence="9"3.6.1.74 alternativeName: mRNA 5'-phosphatase /domain domain recommendedName: mRNA guanylyltransferase ecNumber evidence="9"2.7.7.50 alternativeName: GTP--RNA guanylyltransferase shortName: GTase /domain
geneName	RNGTT CAP1A
identifier	O60942
isSequenceChanged	FALSE
keyword	3D-structure Alternative splicing GTP-binding Host-virus interaction Hydrolase mRNA capping mRNA processing Multifunctional enzyme Nucleotide-binding Nucleotidyltransferase Nucleus Protein phosphatase Proteomics identification Reference proteome Transferase
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name	RNGTT
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8991967] ENSEMBL:ENSG00000111880 RNGTT [Homo sapiens]
secondaryIdentifier	MCE1_HUMAN E1P513 E1P514 O43483 O60257 O60351 Q5TCW8 Q8WUM8
sequenceLength	597
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:150137] UniProt:O60942-2 RNGTT [Homo sapiens] [ReferenceIsoform:150138] UniProt:O60942-3 RNGTT [Homo sapiens] [ReferenceIsoform:150139] UniProt:O60942-4 RNGTT [Homo sapiens] [ReferenceIsoform:401738] UniProt:O60942-1 RNGTT [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:72081] RNGTT [nucleoplasm] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:O60942 RNGTT (72080)