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Details on Person UniProt:O60508 CDC40
| Class:Id | ReferenceGeneProduct:72061 |
|---|---|
| _chainChangeLog | chain:1-579 added on Fri February 6 2015 |
| _displayName | UniProt:O60508 CDC40 |
| _timestamp | 2024-11-03 19:42:51 |
| chain | chain:1-579 |
| checksum | 1DE2BAA6F03FF16D |
| comment | FUNCTION Required for pre-mRNA splicing as component of the activated spliceosome (PubMed:33220177). Plays an important role in embryonic brain development; this function does not require proline isomerization (PubMed:33220177).SUBUNIT Component of the pre-catalytic and catalytic spliceosome complexes (PubMed:11991638, PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106, PubMed:29361316). Component of the postcatalytic spliceosome P complex (PubMed:30705154). Interacts with PPIL1; this interaction leads to CDC40 isomerization (PubMed:33220177).INTERACTION Undergoes isomerization of the peptide bond between Gly-94 and Pro-95. The reaction is catalyzed by PPIL1.DISEASE The disease is caused by variants affecting the gene represented in this entry. |
| description | recommendedName: Pre-mRNA-processing factor 17 alternativeName: Cell division cycle 40 homolog alternativeName: EH-binding protein 3 shortName: Ehb3 alternativeName: PRP17 homolog shortName: hPRP17 |
| geneName | CDC40 EHB3 PRP17 PRPF17 |
| identifier | O60508 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Disease variant Intellectual disability mRNA processing mRNA splicing Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat Spliceosome WD repeat |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CDC40 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8994441] ENSEMBL:ENSG00000168438 CDC40 [Homo sapiens] |
| secondaryIdentifier | PRP17_HUMAN B2RBC5 O75471 Q5SRN0 Q9UPG1 |
| sequenceLength | 579 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:72062] CDC40 [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O60508 CDC40 (72061)
