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Details on Person UniProt:P84103 SRSF3
| Class:Id | ReferenceGeneProduct:72034 |
|---|---|
| _chainChangeLog | chain:1-164 added on Fri February 6 2015 |
| _displayName | UniProt:P84103 SRSF3 |
| _timestamp | 2024-11-03 19:43:36 |
| chain | chain:1-164 |
| checksum | 02F0A5EE33FF28A0 |
| comment | FUNCTION Splicing factor, which binds the consensus motif 5'-C[ACU][AU]C[ACU][AC]C-3' within pre-mRNA and promotes specific exons inclusion during alternative splicing (PubMed:17036044, PubMed:26876937, PubMed:32440474). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites within exons (PubMed:26876937). Also functions as an adapter involved in mRNA nuclear export (PubMed:11336712, PubMed:18364396, PubMed:28984244). Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity (PubMed:11336712, PubMed:18364396). Involved in nuclear export of m6A-containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244).SUBUNIT Interacts with CPSF6 (PubMed:15169763). Interacts with RBMY1A1 (PubMed:15595951). Interacts with SREK1/SFRS12 (PubMed:10757789). Interacts with NXF1 (PubMed:12667464, PubMed:17036044). Interacts with YTHDC1, leading to recruitment to RNA elements adjacent to m6A sites (PubMed:26876937, PubMed:28984244). Interacts with SRSP; increases SRSF3 binding to specific exons (PubMed:32440474).INTERACTION Recruited to nuclear speckles following interaction with YTHDC1.ALTERNATIVE PRODUCTS Phosphorylated by CLK1, CLK2, CLK3 and CLK4. Extensively phosphorylated on serine residues in the RS domain.SIMILARITY Belongs to the splicing factor SR family. |
| description | recommendedName: Serine/arginine-rich splicing factor 3 alternativeName: Pre-mRNA-splicing factor SRP20 alternativeName: Splicing factor, arginine/serine-rich 3 |
| geneName | SRSF3 SFRS3 SRP20 |
| identifier | P84103 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Cytoplasm Direct protein sequencing mRNA processing mRNA splicing mRNA transport Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat RNA-binding Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | SRSF3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8989844] ENSEMBL:ENSG00000112081 SRSF3 [Homo sapiens] |
| secondaryIdentifier | SRSF3_HUMAN B4E241 O08831 P23152 Q5R3K0 |
| sequenceLength | 164 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8971682] UniProt:P84103-1 SRSF3 [Homo sapiens] [ReferenceIsoform:8971683] UniProt:P84103-2 SRSF3 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:72035] SRSF3 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P84103 SRSF3 (72034)
