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Details on Person UniProt:Q01130 SRSF2
| Class:Id | ReferenceGeneProduct:72032 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-221 added on Sat February 7 2015;initiator methionine:1 for 72032 removed on Fri Nov 03 2023;initiator methionine: for 72032 added on Fri Nov 03 2023;initiator methionine: for 72032 removed on Fri Aug 15 2025;initiator methionine:1 for 72032 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q01130 SRSF2 |
| _timestamp | 2025-08-15 21:26:43 |
| chain | initiator methionine:1 chain:2-221 |
| checksum | 68121AC4D35714FA |
| comment | FUNCTION Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment.SUBUNIT Interacts with BRDT (By similarity). In vitro, self-associates and binds SRSF1/SFRS1 (ASF/SF2), SNRNP70 and U2AF1 but not U2AF2. Binds SREK1/SFRS12. Interacts with CCNL1 and CCNL2. Interacts with SCAF11. Interacts with ZRSR2/U2AF1-RS2. Interacts with CCDC55 (via C-terminus).INTERACTION Phosphorylation by SRPK2 provokes its redistribution from the nuclear speckle to nucleoplasm.ALTERNATIVE PRODUCTS Accumulates in a hypoacetylated/phosphorylated form in response to cisplatin treatment.PTM Extensively phosphorylated on serine residues in the RS domain. Phosphorylated by SRPK2 and this causes its redistribution from the nuclear speckle to nucleoplasm and controls cell fate decision in response to cisplatin treatment. KAT5/TIP60 inhibits its phosphorylation by preventing SRPK2 nuclear translocation.PTM Acetylation on Lys-52 by KAT5/TIP60 promotes its proteasomal degradation. This effect is counterbalanced by HDAC6, which positively controls SRSF2 protein level by deacetylating it and preventing its proteasomal degradation.SIMILARITY Belongs to the splicing factor SR family. |
| description | recommendedName: Serine/arginine-rich splicing factor 2 alternativeName: Protein PR264 alternativeName: Splicing component, 35 kDa alternativeName: Splicing factor SC35 shortName: SC-35 alternativeName: Splicing factor, arginine/serine-rich 2 |
| geneName | SRSF2 SFRS2 |
| identifier | Q01130 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Direct protein sequencing mRNA processing mRNA splicing Nucleus Phosphoprotein Proteomics identification Reference proteome RNA-binding |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | SRSF2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9002067] ENSEMBL:ENSG00000161547 SRSF2 [Homo sapiens] |
| secondaryIdentifier | SRSF2_HUMAN B3KWD5 B4DN89 H0YG49 |
| sequenceLength | 221 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8977631] UniProt:Q01130-1 SRSF2 [Homo sapiens] [ReferenceIsoform:8977632] UniProt:Q01130-2 SRSF2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:72033] SRSF2 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q01130 SRSF2 (72032)
