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Details on Person UniProt:Q13243 SRSF5
| Class:Id | ReferenceGeneProduct:72027 |
|---|---|
| _chainChangeLog | chain:1-272 added on Fri February 6 2015 |
| _displayName | UniProt:Q13243 SRSF5 |
| _timestamp | 2024-11-03 19:43:37 |
| chain | chain:1-272 |
| checksum | F13AD79845ECBB16 |
| comment | FUNCTION Plays a role in constitutive splicing and can modulate the selection of alternative splice sites.SUBUNIT Interacts (via RS domain) with PHF5A (via N-terminus) (By similarity). Found in a pre-mRNA splicing complex with SRSF4/SFRS4, SRSF5/SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2.INTERACTION Extensively phosphorylated on serine residues in the RS domain.MISCELLANEOUS May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.SIMILARITY Belongs to the splicing factor SR family. |
| description | recommendedName: Serine/arginine-rich splicing factor 5 alternativeName: Delayed-early protein HRS alternativeName: Pre-mRNA-splicing factor SRP40 alternativeName: Splicing factor, arginine/serine-rich 5 |
| geneName | SRSF5 HRS SFRS5 SRP40 |
| identifier | Q13243 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Alternative splicing Direct protein sequencing mRNA processing mRNA splicing Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat RNA-binding |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | SRSF5 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8990999] ENSEMBL:ENSG00000100650 SRSF5 [Homo sapiens] |
| secondaryIdentifier | SRSF5_HUMAN O14797 Q16662 Q49AD6 Q6FGE0 |
| sequenceLength | 272 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:153768] UniProt:Q13243-2 SRSF5 [Homo sapiens] [ReferenceIsoform:153769] UniProt:Q13243-4 SRSF5 [Homo sapiens] [ReferenceIsoform:153770] UniProt:Q13243-3 SRSF5 [Homo sapiens] [ReferenceIsoform:405578] UniProt:Q13243-1 SRSF5 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:72028] SRSF5 [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q13243 SRSF5 (72027)
