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Details on Person UniProt:O94913 PCF11
| Class:Id | ReferenceGeneProduct:72018 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-1555 added on Fri February 6 2015;initiator methionine:1 for 72018 removed on Fri Nov 03 2023;initiator methionine: for 72018 added on Fri Nov 03 2023;initiator methionine: for 72018 removed on Fri Aug 15 2025;initiator methionine:1 for 72018 added on Fri Aug 15 2025 |
| _displayName | UniProt:O94913 PCF11 |
| _timestamp | 2025-08-15 21:17:38 |
| chain | initiator methionine:1 chain:2-1555 |
| checksum | 0AEAE04D7CB4A34F |
| comment | FUNCTION Component of pre-mRNA cleavage complex II, which promotes transcription termination by RNA polymerase II.SUBUNIT Associates with the phosphorylated CTD domain of POLR2A /RNA polymerase II.INTERACTION Phosphorylation at Ser-120 and/or Thr-121 by WNK1 weakens its association with POLR2A/RNA polymerase II, promoting transcript release from the chromatin template and mRNA export to the cytoplasm.SEQUENCE CAUTION Contaminating sequence. Potential poly-A sequence. |
| description | recommendedName: fullName evidence="8"Pre-mRNA cleavage complex 2 protein Pcf11 alternativeName: Pre-mRNA cleavage complex II protein Pcf11 |
| geneName | PCF11 KIAA0824 |
| identifier | O94913 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Coiled coil Isopeptide bond Methylation mRNA processing Nucleus Phosphoprotein Proteomics identification Reference proteome Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | PCF11 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8995033] ENSEMBL:ENSG00000165494 PCF11 [Homo sapiens] |
| secondaryIdentifier | PCF11_HUMAN A6H8W7 O43671 Q6P0X8 |
| sequenceLength | 1555 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:72019] PCF11 [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O94913 PCF11 (72018)
